DegronMD

Uniprot ID: Q9C0A6

Source protein: Histone-lysine N-methyltransferase SETD5

Source gene: SETD5

Class: DEG_APCC_KENBOX_2

Location: 1078:1082

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5556

ASA_SCORE: 106.14

COIL: 0.862

CONS_SCORE: 0.4679

DSS_SCORE: 0.6836

HELIX: 0.1126

FCONS_SCORE: 0.9184

RIG_SCORE: 0.6167

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1078S	DO229211	THCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.7069
p.E1080D	TCGA-EO-A22U	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.6758
p.S1082Y	TCGA-E6-A1M0	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.6009
p.A1083D	TCGA-IB-7651	PAAD	TCGA	AKENS	DEG_APCC_KENBOX_2	0.3056
p.K1083E	DO228600	MALY	ICGC	AKENS	DEG_APCC_KENBOX_2	0.3056
p.K1083E	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AKENS	DEG_APCC_KENBOX_2	0.3056
p.Q1076P	TCGA-DX-A8BP	SARC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.2778
p.P1076L	DO219091	BLCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.2778
p.G1085W	TCGA-FS-A1ZP	SKCM	TCGA	AKENS	DEG_APCC_KENBOX_2	0.25
p.G1085W	SIDM00394	Cervical Carcinoma	GDSC	AKENS	DEG_APCC_KENBOX_2	0.25
p.G1085W	ACH-001650	Cervical Cancer	CCLE	AKENS	DEG_APCC_KENBOX_2	0.25
p.G1085W	SISO	cervix	COSMIC	AKENS	DEG_APCC_KENBOX_2	0.25
p.G1085E	TCGA-ZF-A9R4	BLCA	TCGA	AKENS	DEG_APCC_KENBOX_2	0.25
p.R1074Q	TCGA-G4-6628	COAD	TCGA	AKENS	DEG_APCC_KENBOX_2	0.2222
p.L1087M	DO47374	SKCM	ICGC	AKENS	DEG_APCC_KENBOX_2	0.1944
p.L1087P	DO229257	THCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.1944
p.R1072Q	TCGA-BR-A4QL	STAD	TCGA	AKENS	DEG_APCC_KENBOX_2	0.1667
p.R1072Q	TCGA-D1-A16X	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.1667
p.R1072Q	TCGA-D3-A8GK	SKCM	TCGA	AKENS	DEG_APCC_KENBOX_2	0.1667
p.V1072F	NCI-H460	lung	COSMIC	AKENS	DEG_APCC_KENBOX_2	0.1667
p.R1091Q	DO50286	SKCM	ICGC	AKENS	DEG_APCC_KENBOX_2	0.0833
p.R1091Q	DO38723	STAD	ICGC	AKENS	DEG_APCC_KENBOX_2	0.0833
p.R1091Q	DO41799	UCEC	ICGC	AKENS	DEG_APCC_KENBOX_2	0.0833
p.L1068M	TCGA-BF-A1Q0	SKCM	TCGA	AKENS	DEG_APCC_KENBOX_2	0.0556
p.A1068T	NB1	autonomic_ganglia	COSMIC	AKENS	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 25 of 25 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0A6	Histone-lysine N-methyltransferase SETD5	DEG_APCC_KENBOX_2	1078:1082	AKENS	APC,CDC20,FZR1	0.5556	More...
Q9UHV9	Prefoldin subunit 2	DEG_APCC_KENBOX_2	135:139	AKENS	APC,CDC20,FZR1	0.6125	More...
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_KENBOX_2	1474:1478	AKENS	APC,CDC20,FZR1	0.8676	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	484:488	AKENS	APC,CDC20,FZR1	0.9942	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	110:114	AKENS	APC,CDC20,FZR1	0.6159	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons