DegronMD

Uniprot ID: Q9BXT5

Source protein: Testis-expressed protein 15

Source gene: TEX15

Class: DEG_APCC_KENBOX_2

Location: 484:488

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9942

ASA_SCORE: 96.72

COIL: 0.5308

CONS_SCORE: 0.5694

DSS_SCORE: 0.5851

HELIX: 0.448

FCONS_SCORE: 1.2916

RIG_SCORE: 0.7026

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A484T	TCGA-AC-A4ZE	BRCA	TCGA	AKENS	DEG_APCC_KENBOX_2	0.6028
p.A484T	DO223930	BRCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.6028
p.E493Q	TCGA-EK-A2RA	CESC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.1944
p.E493Q	DO51601	CESC	ICGC	AKENS	DEG_APCC_KENBOX_2	0.1944
p.N480K	DO233746	GACA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.2222
p.E486K	DO228948	LICA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.7022
p.E483K	ACH-001390	Breast Cancer	CCLE	AKENS	DEG_APCC_KENBOX_2	0.3056
p.R478T	ACH-001390	Breast Cancer	CCLE	AKENS	DEG_APCC_KENBOX_2	0.1667
p.E497Q	ACH-001414	Bladder Cancer	CCLE	AKENS	DEG_APCC_KENBOX_2	0.0833
p.R478I	NCI-H630	large_intestine	COSMIC	AKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_KENBOX_2	1474:1478	AKENS	APC,CDC20,FZR1	0.8676	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	110:114	AKENS	APC,CDC20,FZR1	0.6159	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	484:488	AKENS	APC,CDC20,FZR1	0.9942	More...
Q9C0A6	Histone-lysine N-methyltransferase SETD5	DEG_APCC_KENBOX_2	1078:1082	AKENS	APC,CDC20,FZR1	0.5556	More...
Q9UHV9	Prefoldin subunit 2	DEG_APCC_KENBOX_2	135:139	AKENS	APC,CDC20,FZR1	0.6125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons