DegronMD - Q9UHV9(PFDN2)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R125H	TCGA-B5-A3FC	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation rewiring degron network	0.0556
p.R125H	DO41871	UCEC	ICGC	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation rewiring degron network	0.0556
p.E129K	TCGA-CR-6484	HNSC	TCGA	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation rewiring degron network	0.1667
p.E129K	DO15206	HNSC	ICGC	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation rewiring degron network	0.1667
p.G128R	TCGA-L7-A56G	ESCA	TCGA	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation rewiring degron network	0.1389
p.R125C	TCGA-UY-A78L	BLCA	TCGA	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation rewiring degron network	0.0556
p.R125C	DO219032	BLCA	ICGC	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation rewiring degron network	0.0556
p.R125C	DO218840	SKCA	ICGC	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation rewiring degron network	0.0556
p.A142D	DO229026	LICA	ICGC	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation rewiring degron network	0.25
p.N138S	SIDM00704	Small Cell Lung Carcinoma	GDSC	AKENS	DEG_APCC_KENBOX_2	135:139	Mutation altering degron motif	0.7069

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons