DegronMD

Uniprot ID: Q9UHV9

Source protein: Prefoldin subunit 2

Source gene: PFDN2

Class: DEG_APCC_KENBOX_2

Location: 135:139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6125

ASA_SCORE: 105.48

COIL: 0.668

CONS_SCORE: 0.4793

DSS_SCORE: 0.6436

HELIX: 0.3256

FCONS_SCORE: 0.9073

RIG_SCORE: 0.6494

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R125H	TCGA-B5-A3FC	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.0556
p.R125H	DO41871	UCEC	ICGC	AKENS	DEG_APCC_KENBOX_2	0.0556
p.E129K	TCGA-CR-6484	HNSC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.1667
p.E129K	DO15206	HNSC	ICGC	AKENS	DEG_APCC_KENBOX_2	0.1667
p.G128R	TCGA-L7-A56G	ESCA	TCGA	AKENS	DEG_APCC_KENBOX_2	0.1389
p.R125C	TCGA-UY-A78L	BLCA	TCGA	AKENS	DEG_APCC_KENBOX_2	0.0556
p.R125C	DO219032	BLCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.0556
p.R125C	DO218840	SKCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.0556
p.A142D	DO229026	LICA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.25
p.N138S	SIDM00704	Small Cell Lung Carcinoma	GDSC	AKENS	DEG_APCC_KENBOX_2	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_KENBOX_2	1474:1478	AKENS	APC,CDC20,FZR1	0.8676	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	110:114	AKENS	APC,CDC20,FZR1	0.6159	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	484:488	AKENS	APC,CDC20,FZR1	0.9942	More...
Q9C0A6	Histone-lysine N-methyltransferase SETD5	DEG_APCC_KENBOX_2	1078:1082	AKENS	APC,CDC20,FZR1	0.5556	More...
Q9UHV9	Prefoldin subunit 2	DEG_APCC_KENBOX_2	135:139	AKENS	APC,CDC20,FZR1	0.6125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons