DegronMD

Uniprot ID: Q5T6F2

Source protein: Ubiquitin-associated protein 2

Source gene: UBAP2

Class: DEG_APCC_KENBOX_2

Location: 110:114

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6159

ASA_SCORE: 107.36

COIL: 0.799

CONS_SCORE: 0.4136

DSS_SCORE: 0.5321

HELIX: 0.194

FCONS_SCORE: 0.695

RIG_SCORE: 0.6932

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E100K	TCGA-3A-A9IL	PAAD	TCGA	AKENS	DEG_APCC_KENBOX_2	0.0556
p.E100K	DO218956	PAAD	ICGC	AKENS	DEG_APCC_KENBOX_2	0.0556
p.K105N	TCGA-A5-A0G2	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.3056
p.K105N	DO41235	UCEC	ICGC	AKENS	DEG_APCC_KENBOX_2	0.3056
p.K122N	TCGA-E6-A1LX	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.2222
p.K122N	DO41020	UCEC	ICGC	AKENS	DEG_APCC_KENBOX_2	0.2222
p.K107N	TCGA-EO-A3B0	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.3611
p.K107N	DO219773	UCEC	ICGC	AKENS	DEG_APCC_KENBOX_2	0.3611
p.K107N	SIDM00118	Colorectal Carcinoma	GDSC	AKENS	DEG_APCC_KENBOX_2	0.3611
p.K107N	ACH-001081	Colon/Colorectal Cancer	CCLE	AKENS	DEG_APCC_KENBOX_2	0.3611
p.K107N	HCC2998	large_intestine	COSMIC	AKENS	DEG_APCC_KENBOX_2	0.3611
p.N108I	TCGA-ER-A194	SKCM	TCGA	AKENS	DEG_APCC_KENBOX_2	0.2778
p.N108I	DO47646	SKCM	ICGC	AKENS	DEG_APCC_KENBOX_2	0.2778
p.S114L	DO48453	BLCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.6556
p.E121K	DO229364	BTCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.1389
p.D112E	DO229019	LICA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.6758
p.R110S	DO229032	LICA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.7427
p.T101N	DO229037	LICA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.0833
p.F108V	DO24441	LUAD	ICGC	AKENS	DEG_APCC_KENBOX_2	0.2778
p.P102A	DO46448	OV	ICGC	AKENS	DEG_APCC_KENBOX_2	0.1111
p.A123T	DO229257	THCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.1944
p.D112N	DO229240	THCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.6932
p.A110T	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	AKENS	DEG_APCC_KENBOX_2	0.6028
p.A110T	ACH-000395	Lung Cancer	CCLE	AKENS	DEG_APCC_KENBOX_2	0.6028
p.A110T	NCI-H520	lung	COSMIC	AKENS	DEG_APCC_KENBOX_2	0.6028
p.F108C	ES-2	ovary	COSMIC	AKENS	DEG_APCC_KENBOX_2	0.2778
p.G111E	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	AKENS	DEG_APCC_KENBOX_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_KENBOX_2	1474:1478	AKENS	APC,CDC20,FZR1	0.8676	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	110:114	AKENS	APC,CDC20,FZR1	0.6159	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	484:488	AKENS	APC,CDC20,FZR1	0.9942	More...
Q9C0A6	Histone-lysine N-methyltransferase SETD5	DEG_APCC_KENBOX_2	1078:1082	AKENS	APC,CDC20,FZR1	0.5556	More...
Q9UHV9	Prefoldin subunit 2	DEG_APCC_KENBOX_2	135:139	AKENS	APC,CDC20,FZR1	0.6125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKENS

Degron related mutations and impact score

Drug responses associated with UBAP2 mutations

All proteins holding degron of AKENS