DegronMD - Q9C0A6(SETD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1021S	TCGA-3N-A9WC	SKCM	TCGA	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation rewiring degron network	0.1667
p.R882Q	TCGA-AJ-A5DW	UCEC	TCGA	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.1111
p.R882Q	TCGA-B5-A1MR	UCEC	TCGA	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.1111
p.R882Q	TCGA-D1-A17Q	UCEC	TCGA	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.1111
p.R882Q	ACH-000231	Brain Cancer	CCLE	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.1111
p.R882Q	ACH-000938	Leukemia	CCLE	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.1111
p.R882Q	ACH-000974	Endometrial/Uterine Cancer	CCLE	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.1111
p.G79E	TCGA-B5-A0JY	UCEC	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111
p.L1068M	TCGA-BF-A1Q0	SKCM	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.0556
p.I61V	TCGA-BR-4184	STAD	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.I61V	DO38328	STAD	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.R1072Q	TCGA-BR-A4QL	STAD	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.1667
p.R1072Q	TCGA-D1-A16X	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.1667
p.R1072Q	TCGA-D3-A8GK	SKCM	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.1667
p.Q1076P	TCGA-DX-A8BP	SARC	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.2778
p.S1082Y	TCGA-E6-A1M0	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation altering degron motif	0.6009
p.E1023D	TCGA-EO-A22R	UCEC	TCGA	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation rewiring degron network	0.1111
p.E1080D	TCGA-EO-A22U	UCEC	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation altering degron motif	0.6758
p.R64S	TCGA-ER-A19B	SKCM	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7427
p.R64S	DO47491	SKCM	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7427
p.G1085W	TCGA-FS-A1ZP	SKCM	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.25
p.G1085W	SIDM00394	Cervical Carcinoma	GDSC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.25
p.G1085W	ACH-001650	Cervical Cancer	CCLE	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.25
p.G1085W	SISO	cervix	COSMIC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.25
p.R1074Q	TCGA-G4-6628	COAD	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.2222
p.S72L	TCGA-HT-A74J	LGG	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.S72L	SIDM00527	Colorectal Carcinoma	GDSC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.S72L	ACH-000935	Colon/Colorectal Cancer	CCLE	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.S72L	MDST8	large intestine	COSMIC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.A1083D	TCGA-IB-7651	PAAD	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.3056
p.P859L	TCGA-VQ-A8P2	STAD	TCGA	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.0833
p.R77C	TCGA-XK-AAIW	PRAD	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.G1085E	TCGA-ZF-A9R4	BLCA	TCGA	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.25
p.P72S	DO218988	BLCA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.P72S	DO222413	MELA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.P1076L	DO219091	BLCA	ICGC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.2778
p.A65S	DO225004	BRCA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7588
p.S74C	DO9218	COAD	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.S871F	DO48298	ESCA	ICGC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7982
p.P69L	DO233942	GACA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7582
p.V873L	DO21571	LAML	ICGC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.6765
p.V74L	DO228948	LICA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.A71S	DO228985	LICA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7588
p.A79S	DO229037	LICA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111
p.S884I	DO229006	LICA	ICGC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.0556
p.E76V	DO23332	LINC	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1944
p.Y1004C	DO45203	LIRI	ICGC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation rewiring degron network	0.1944
p.A1015T	DO26250	LUAD	ICGC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.7139
p.K1083E	DO228600	MALY	ICGC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.3056
p.K1083E	DND-41	haematopoietic and lymphoid tissue	COSMIC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.3056
p.E999K	DO220886	MELA	ICGC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation rewiring degron network	0.0556
p.P69S	DO222843	MELA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6752
p.S64N	DO46542	OV	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7069
p.P76S	DO47268	SKCM	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1944
p.R1091Q	DO50286	SKCM	ICGC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.0833
p.R1091Q	DO38723	STAD	ICGC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.0833
p.R1091Q	DO41799	UCEC	ICGC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.0833
p.D1016G	DO50288	SKCM	ICGC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation rewiring degron network	0.3056
p.L1087M	DO47374	SKCM	ICGC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.1944
p.P878L	DO51761	STAD	ICGC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.2222
p.L1087P	DO229257	THCA	ICGC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.1944
p.N1078S	DO229211	THCA	ICGC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation altering degron motif	0.7069
p.R81Q	DO219773	UCEC	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0556
p.K73Q	DO43041	UCEC	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.S874F	SIDM00663	Melanoma	GDSC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7982
p.S874F	ACH-000814	Skin Cancer	CCLE	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7982
p.S874F	Hs939-T	skin	COSMIC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7982
p.R77H	SIDM01090	Colorectal Carcinoma	GDSC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.R77H	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.R77H	SIDM01387	Small Cell Lung Carcinoma	GDSC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.M1012V	NCI-H1694	lung	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.7208
p.H868Y	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7229
p.M859T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.0833
p.V1072F	NCI-H460	lung	COSMIC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.1667
p.P58A	RERF-LC-MS	lung	COSMIC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1944
p.H1015R	NCC010	kidney	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.8244
p.H1015R	KOSC-2	upper aerodigestive tract	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.8244
p.H1015R	SNU-81	large intestine	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.8244
p.Q877R	OVISE	ovary	COSMIC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation rewiring degron network	0.25
p.A1068T	NB1	autonomic ganglia	COSMIC	AKENS	DEG_APCC_KENBOX_2	1078:1082	Mutation rewiring degron network	0.0556
p.H1015Q	SNU-C5	large intestine	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SETD5

UniProt ID: Q9C0A6

Entrez ID: 55209

Protein name: Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SETD5 in