DegronMD - Q9C0A6(SETD5)

FUNCTION: Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}.

GO - Biological processes (BP): chromatin organization [GO:0006325]; cognition [GO:0050890]; histone H3-K36 trimethylation [GO:0097198]; regulation of chromatin organization [GO:1902275]; regulation of DNA-templated transcription, elongation [GO:0032784]; regulation of histone acetylation [GO:0035065]; regulation of synapse assemb... View more >>

GO - Molecular function (MF): histone methyltransferase activity (H3-K36 specific) [GO:0046975]; histone methyltransferase activity (H3-K9 specific) [GO:0046974]

GO - Cellular component (CC): Cdc73/Paf1 complex [GO:0016593]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PRSDLNGLP	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Histone-lysine N-methyltransferase SETD5	63:71	More..
AKENS	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	Histone-lysine N-methyltransferase SETD5	1078:1082	More..
LATPGSS	DEG_SCF_FBW7_1	FBXW7	Histone-lysine N-methyltransferase SETD5	868:874	More..
RKPLHLD	LIG_APCC_ABBAyCdc20_2	APC,CDC20,FZR1	Histone-lysine N-methyltransferase SETD5	1009:1015	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H1015R	NCC010	kidney	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.8244
p.H1015R	KOSC-2	upper aerodigestive tract	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.8244
p.H1015R	SNU-81	large intestine	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.8244
p.S871F	DO48298	ESCA	ICGC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7982
p.S874F	SIDM00663	Melanoma	GDSC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7982
p.S874F	ACH-000814	Skin Cancer	CCLE	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7982
p.S874F	Hs939-T	skin	COSMIC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7982
p.A65S	DO225004	BRCA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7588
p.A71S	DO228985	LICA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7588
p.P69L	DO233942	GACA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7582
p.H1015Q	SNU-C5	large intestine	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	1009:1015	Mutation altering degron motif	0.7582
p.S72L	TCGA-HT-A74J	LGG	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.S72L	SIDM00527	Colorectal Carcinoma	GDSC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.S72L	ACH-000935	Colon/Colorectal Cancer	CCLE	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.S72L	MDST8	large intestine	COSMIC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.P72S	DO218988	BLCA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.P72S	DO222413	MELA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation blocking phosphorylation signal	0.75
p.R64S	TCGA-ER-A19B	SKCM	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7427
p.R64S	DO47491	SKCM	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7427
p.H868Y	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	LATPGSS	DEG_SCF_FBW7_1	868:874	Mutation altering degron motif	0.7229

Showing 1 to 20 of 81 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

SETD5

UniProt ID: Q9C0A6

Entrez ID: 55209

Protein name: Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SETD5 in