DegronMD

Uniprot ID: Q9C0A6

Source protein: Histone-lysine N-methyltransferase SETD5

Source gene: SETD5

Class: LIG_APCC_ABBAyCdc20_2

Location: 1009:1015

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9065

ASA_SCORE: 102.5857

COIL: 0.8933

CONS_SCORE: 0.4818

DSS_SCORE: 0.3502

HELIX: 0.0423

FCONS_SCORE: 0.9742

RIG_SCORE: 0.7192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1021S	TCGA-3N-A9WC	SKCM	TCGA	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E1023D	TCGA-EO-A22R	UCEC	TCGA	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Y1004C	DO45203	LIRI	ICGC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A1015T	DO26250	LUAD	ICGC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.7139
p.E999K	DO220886	MELA	ICGC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D1016G	DO50288	SKCM	ICGC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.M1012V	NCI-H1694	lung	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.7208
p.H1015R	NCC010	kidney	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.8244
p.H1015R	KOSC-2	upper_aerodigestive_tract	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.8244
p.H1015R	SNU-81	large_intestine	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.8244
p.H1015Q	SNU-C5	large_intestine	COSMIC	RKPLHLD	LIG_APCC_ABBAyCdc20_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0A6	Histone-lysine N-methyltransferase SETD5	LIG_APCC_ABBAyCdc20_2	1009:1015	RKPLHLD	APC,CDC20,FZR1	0.9065	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons