DegronMD

Uniprot ID: Q9C0A6

Source protein: Histone-lysine N-methyltransferase SETD5

Source gene: SETD5

Class: DEG_SCF_FBW7_1

Location: 868:874

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 69.4714

COIL: 0.9377

CONS_SCORE: 0.4902

DSS_SCORE: 0.7454

HELIX: 0.027

FCONS_SCORE: 1.0725

RIG_SCORE: 0.5186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R882Q	TCGA-AJ-A5DW	UCEC	TCGA	LATPGSS	DEG_SCF_FBW7_1	0.1111
p.R882Q	TCGA-B5-A1MR	UCEC	TCGA	LATPGSS	DEG_SCF_FBW7_1	0.1111
p.R882Q	TCGA-D1-A17Q	UCEC	TCGA	LATPGSS	DEG_SCF_FBW7_1	0.1111
p.R882Q	ACH-000231	Brain Cancer	CCLE	LATPGSS	DEG_SCF_FBW7_1	0.1111
p.R882Q	ACH-000938	Leukemia	CCLE	LATPGSS	DEG_SCF_FBW7_1	0.1111
p.R882Q	ACH-000974	Endometrial/Uterine Cancer	CCLE	LATPGSS	DEG_SCF_FBW7_1	0.1111
p.P859L	TCGA-VQ-A8P2	STAD	TCGA	LATPGSS	DEG_SCF_FBW7_1	0.0833
p.S871F	DO48298	ESCA	ICGC	LATPGSS	DEG_SCF_FBW7_1	0.7982
p.V873L	DO21571	LAML	ICGC	LATPGSS	DEG_SCF_FBW7_1	0.6765
p.S884I	DO229006	LICA	ICGC	LATPGSS	DEG_SCF_FBW7_1	0.0556
p.P878L	DO51761	STAD	ICGC	LATPGSS	DEG_SCF_FBW7_1	0.2222
p.S874F	SIDM00663	Melanoma	GDSC	LATPGSS	DEG_SCF_FBW7_1	0.7982
p.S874F	ACH-000814	Skin Cancer	CCLE	LATPGSS	DEG_SCF_FBW7_1	0.7982
p.S874F	Hs939-T	skin	COSMIC	LATPGSS	DEG_SCF_FBW7_1	0.7982
p.H868Y	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	LATPGSS	DEG_SCF_FBW7_1	0.7229
p.M859T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LATPGSS	DEG_SCF_FBW7_1	0.0833
p.Q877R	OVISE	ovary	COSMIC	LATPGSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0A6	Histone-lysine N-methyltransferase SETD5	DEG_SCF_FBW7_1	868:874	LATPGSS	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons