DegronMD

Uniprot ID: Q9C0A6

Source protein: Histone-lysine N-methyltransferase SETD5

Source gene: SETD5

Class: DEG_APCC_DBOX_1

Location: 63:71

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9926

ASA_SCORE: 78.1778

COIL: 0.8439

CONS_SCORE: 0.4812

DSS_SCORE: 0.4728

HELIX: 0.1246

FCONS_SCORE: 0.8853

RIG_SCORE: 0.7002

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G79E	TCGA-B5-A0JY	UCEC	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	0.1111
p.I61V	TCGA-BR-4184	STAD	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	0.2778
p.I61V	DO38328	STAD	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.2778
p.R64S	TCGA-ER-A19B	SKCM	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	0.7427
p.R64S	DO47491	SKCM	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.7427
p.S72L	TCGA-HT-A74J	LGG	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	0.75
p.S72L	SIDM00527	Colorectal Carcinoma	GDSC	PRSDLNGLP	DEG_APCC_DBOX_1	0.75
p.S72L	ACH-000935	Colon/Colorectal Cancer	CCLE	PRSDLNGLP	DEG_APCC_DBOX_1	0.75
p.S72L	MDST8	large_intestine	COSMIC	PRSDLNGLP	DEG_APCC_DBOX_1	0.75
p.R77C	TCGA-XK-AAIW	PRAD	TCGA	PRSDLNGLP	DEG_APCC_DBOX_1	0.1667
p.P72S	DO218988	BLCA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.75
p.P72S	DO222413	MELA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.75
p.A65S	DO225004	BRCA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.7588
p.S74C	DO9218	COAD	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.25
p.P69L	DO233942	GACA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.7582
p.V74L	DO228948	LICA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.25
p.A71S	DO228985	LICA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.7588
p.A79S	DO229037	LICA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.1111
p.E76V	DO23332	LINC	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.1944
p.P69S	DO222843	MELA	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.6752
p.S64N	DO46542	OV	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.7069
p.P76S	DO47268	SKCM	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.1944
p.R81Q	DO219773	UCEC	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.0556
p.K73Q	DO43041	UCEC	ICGC	PRSDLNGLP	DEG_APCC_DBOX_1	0.2778
p.R77H	SIDM01090	Colorectal Carcinoma	GDSC	PRSDLNGLP	DEG_APCC_DBOX_1	0.1667
p.R77H	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PRSDLNGLP	DEG_APCC_DBOX_1	0.1667
p.R77H	SIDM01387	Small Cell Lung Carcinoma	GDSC	PRSDLNGLP	DEG_APCC_DBOX_1	0.1667
p.P58A	RERF-LC-MS	lung	COSMIC	PRSDLNGLP	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSDLNGLP

Degron related mutations and impact score

Drug responses associated with SETD5 mutations

All proteins holding degron of PRSDLNGLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0A6	Histone-lysine N-methyltransferase SETD5	DEG_APCC_DBOX_1	63:71	PRSDLNGLP	APC,CDC20,FZR1	0.9926	More...