DegronMD

Uniprot ID: Q5T5U3

Source protein: Rho GTPase-activating protein 21

Source gene: ARHGAP21

Class: DEG_SCF_FBW7_1

Location: 1071:1078

E3 ligase: FBXW7

DEGRON score: 0.9813

ASA_SCORE: 96.6125

COIL: 0.8823

CONS_SCORE: 0.3718

DSS_SCORE: 0.6176

HELIX: 0.0913

FCONS_SCORE: 1.0078

RIG_SCORE: 0.6962

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1087C	TCGA-09-2044	OV	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	0.0833
p.G1087C	DO28923	OV	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	0.0833
p.N1062K	TCGA-13-1509	OV	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	0.0833
p.N1062K	DO30740	OV	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	0.0833
p.R1076C	TCGA-AA-A02R	COAD	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	0.719
p.R1076H	TCGA-CK-4951	COAD	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	0.7133
p.R1076H	DO10582	COAD	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	0.7133
p.R1076H	SIDM00216	Colorectal Carcinoma	GDSC	LPKTPRQS	DEG_SCF_FBW7_1	0.7133
p.R1076H	SIDM00120	Prostate Carcinoma	GDSC	LPKTPRQS	DEG_SCF_FBW7_1	0.7133
p.R1076H	ACH-000979	Prostate Cancer	CCLE	LPKTPRQS	DEG_SCF_FBW7_1	0.7133
p.R1076H	ACH-000989	Colon/Colorectal Cancer	CCLE	LPKTPRQS	DEG_SCF_FBW7_1	0.7133
p.R1076H	SNU-175	large_intestine	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	0.7133
p.R1076H	DU-145	prostate	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	0.7133
p.R1076S	TCGA-D3-A2JC	SKCM	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	0.6316
p.R1076S	DO47578	SKCM	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	0.6316
p.N1063S	TCGA-EO-A22R	UCEC	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	0.1111
p.N1063S	DO42713	UCEC	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	0.1111
p.S1080I	DO35550	PBCA	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	0.7222
p.A1068T	SIDM01519	Head and Neck Carcinoma	GDSC	LPKTPRQS	DEG_SCF_FBW7_1	0.25
p.T1084I	ML-2	haematopoietic_and_lymphoid_tissue	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	0.1667
p.D1085N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	0.1389
p.R1066H	SNU-175	large_intestine	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	0.1944
p.R1066H	DU-145	prostate	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	0.1944
p.A1061V	ES6	bone	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	0.0556
p.D1084N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	0.1667
p.S1065L	QGP-1	pancreas	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPKTPRQS

Degron related mutations and impact score

Drug responses associated with ARHGAP21 mutations

All proteins holding degron of LPKTPRQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_SCF_FBW7_1	1071:1078	LPKTPRQS	FBXW7	0.9813	More...