DegronMD - Q99457(NAP1L3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A14S	TCGA-22-1012	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0833
p.A14S	DO27302	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0833
p.S39R	TCGA-A6-5665	COAD	TCGA	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation blocking phosphorylation signal	0.6111
p.S39R	DO9756	COAD	ICGC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation blocking phosphorylation signal	0.6111
p.A23T	TCGA-AP-A059	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7139
p.A23T	DO41361	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7139
p.S29A	TCGA-B5-A3FA	UCEC	TCGA	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation altering degron motif	0.7588
p.S29A	DO52402	UCEC	ICGC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation altering degron motif	0.7588
p.E19K	TCGA-BS-A0UV	UCEC	TCGA	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.0833
p.E19K	TCGA-BS-A0UV	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2222
p.E19K	DO223130	ESCA	ICGC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.0833
p.E19K	DO223130	ESCA	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2222
p.E19K	DO42793	UCEC	ICGC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.0833
p.E19K	DO42793	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2222
p.A18S	TCGA-CC-A9FW	LIHC	TCGA	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.0556
p.A18S	TCGA-CC-A9FW	LIHC	TCGA	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.A18S	DO219557	LIHC	ICGC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.0556
p.A18S	DO219557	LIHC	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.S25L	TCGA-CK-6746	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7667
p.S25L	TCGA-E7-A5KE	BLCA	TCGA	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7667
p.S25L	DO44048	BLCA	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7667
p.S25L	DO7938	COAD	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7667
p.H15Y	TCGA-ER-A19N	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.H15Y	DO37452	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.S29F	TCGA-FW-A3R5	SKCM	TCGA	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation altering degron motif	0.7982
p.S29F	DO37406	SKCM	ICGC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation altering degron motif	0.7982
p.S24N	TCGA-IM-A3U3	THCA	TCGA	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.5958
p.S24N	DO39086	THCA	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.5958
p.S37R	DO228928	LICA	ICGC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.2222
p.S37R	DO228928	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.M22I	SIDM00781	Colorectal Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.1667
p.M22I	SIDM00781	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.M22I	SIDM00780	Colorectal Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.1667
p.M22I	SIDM00780	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.M22I	ACH-000967	Colon/Colorectal Cancer	CCLE	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.1667
p.M22I	ACH-000967	Colon/Colorectal Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.M22I	ACH-001199	Colon/Colorectal Cancer	CCLE	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.1667
p.M22I	ACH-001199	Colon/Colorectal Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.M22I	SNU-C2B	large intestine	COSMIC	DSGEES	DEG_SCF_TRCP1_1	28:33	Mutation rewiring degron network	0.1667
p.M22I	SNU-C2B	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.G16V	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.G16V	ACH-001498	Lymphoma	CCLE	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.G16V	Farage	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.M15I	SNU-C2B	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NAP1L3

UniProt ID: Q99457

Entrez ID: 4675

Protein name: Nucleosome assembly protein 1-like 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NAP1L3 in