DegronMD

Uniprot ID: Q99457

Source protein: Nucleosome assembly protein 1-like 3

Source gene: NAP1L3

Class: DEG_SCF_TRCP1_1

Location: 28:33

E3 ligase: BTRC

DEGRON score: 0.8883

ASA_SCORE: 95.3333

COIL: 0.9085

CONS_SCORE: 0.5581

DSS_SCORE: 0.6962

HELIX: 0.0673

FCONS_SCORE: 1.1838

RIG_SCORE: 0.5238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S39R	TCGA-A6-5665	COAD	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.6111
p.S39R	DO9756	COAD	ICGC	DSGEES	DEG_SCF_TRCP1_1	0.6111
p.S29A	TCGA-B5-A3FA	UCEC	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.7588
p.S29A	DO52402	UCEC	ICGC	DSGEES	DEG_SCF_TRCP1_1	0.7588
p.E19K	TCGA-BS-A0UV	UCEC	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.0833
p.E19K	DO223130	ESCA	ICGC	DSGEES	DEG_SCF_TRCP1_1	0.0833
p.E19K	DO42793	UCEC	ICGC	DSGEES	DEG_SCF_TRCP1_1	0.0833
p.A18S	TCGA-CC-A9FW	LIHC	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.0556
p.A18S	DO219557	LIHC	ICGC	DSGEES	DEG_SCF_TRCP1_1	0.0556
p.S29F	TCGA-FW-A3R5	SKCM	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.7982
p.S29F	DO37406	SKCM	ICGC	DSGEES	DEG_SCF_TRCP1_1	0.7982
p.S37R	DO228928	LICA	ICGC	DSGEES	DEG_SCF_TRCP1_1	0.2222
p.M22I	SIDM00781	Colorectal Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	0.1667
p.M22I	SIDM00780	Colorectal Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	0.1667
p.M22I	ACH-000967	Colon/Colorectal Cancer	CCLE	DSGEES	DEG_SCF_TRCP1_1	0.1667
p.M22I	ACH-001199	Colon/Colorectal Cancer	CCLE	DSGEES	DEG_SCF_TRCP1_1	0.1667
p.M22I	SNU-C2B	large_intestine	COSMIC	DSGEES	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBB5	Kelch domain-containing protein 4	DEG_SCF_TRCP1_1	511:516	DSGEES	BTRC	0.8231	More...
Q99457	Nucleosome assembly protein 1-like 3	DEG_SCF_TRCP1_1	28:33	DSGEES	BTRC	0.8883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons