DegronMD - Q8TBB5(KLHDC4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S70L	TCGA-55-8089	LUAD	TCGA	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6556
p.S70L	DO23690	LUAD	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6556
p.P73S	TCGA-A2-A0D2	BRCA	TCGA	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5641
p.P73S	TCGA-EE-A3AF	SKCM	TCGA	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5641
p.P73S	DO6072	BRCA	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5641
p.P73S	DO37911	SKCM	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5641
p.E74D	TCGA-A5-A0G2	UCEC	TCGA	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5647
p.E74D	DO41235	UCEC	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5647
p.E504A	TCGA-AP-A054	UCEC	TCGA	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation rewiring degron network	0.1944
p.E504A	TCGA-AP-A054	UCEC	TCGA	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation rewiring degron network	0.1389
p.G513R	TCGA-AR-A0U4	BRCA	TCGA	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.7568
p.G513R	TCGA-AR-A0U4	BRCA	TCGA	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation altering degron motif	0.7568
p.D76Y	TCGA-AX-A2HC	UCEC	TCGA	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2778
p.D76Y	DO41572	UCEC	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2778
p.S62T	TCGA-AZ-6601	COAD	TCGA	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation blocking phosphorylation signal	0.5833
p.S62T	DO8119	COAD	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation blocking phosphorylation signal	0.5833
p.A518V	TCGA-BT-A3PH	BLCA	TCGA	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation rewiring degron network	0.2222
p.A518V	TCGA-BT-A3PH	BLCA	TCGA	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation rewiring degron network	0.2778
p.G506V	TCGA-D3-A2J6	SKCM	TCGA	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation rewiring degron network	0.25
p.G506V	TCGA-D3-A2J6	SKCM	TCGA	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation rewiring degron network	0.1944
p.E515K	TCGA-EB-A5UN	SKCM	TCGA	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation altering degron motif	0.591
p.P73L	TCGA-EE-A3AF	SKCM	TCGA	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6471
p.P73L	DO37911	SKCM	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6471
p.A67V	DO219010	BLCA	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2778
p.A67V	DO223286	UCEC	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2778
p.Q66K	DO229009	LICA	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.25
p.F81L	DO220851	MELA	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1389
p.Q72E	DO32831	PACA	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6744
p.G82W	DO42472	UCEC	ICGC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1111
p.L69V	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5654
p.L69V	SIDM01036	Plasma Cell Myeloma	GDSC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5654
p.L69V	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5654
p.L69V	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5654
p.L69V	SIDM01681	Non-Cancerous	GDSC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5654
p.L69V	SIDM01042	Breast Carcinoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.5654
p.E510K	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.591
p.E510D	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.5647
p.E510D	SIDM00544	Neuroblastoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.5647
p.E510D	SIDM00276	Biliary Tract Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.5647
p.E510D	SIDM00241	Breast Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.5647
p.E510D	SIDM00579	Neuroblastoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.5647
p.E510D	KYSE-180	oesophagus	COSMIC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.5647
p.E510D	GOTO	autonomic ganglia	COSMIC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.5647
p.E510D	OCUB-M	breast	COSMIC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.5647
p.E510D	ETK-1	biliary tract	COSMIC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation altering degron motif	0.5647
p.D508N	SIDM00676	Bladder Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation rewiring degron network	0.3056
p.D508N	SIDM00676	Bladder Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation rewiring degron network	0.25
p.G506R	SIDM01114	Non-Cancerous	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation rewiring degron network	0.25
p.G506R	SIDM01114	Non-Cancerous	GDSC	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation rewiring degron network	0.1944
p.G506R	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation rewiring degron network	0.25
p.G506R	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation rewiring degron network	0.1944
p.G506R	SIDM01680	Non-Cancerous	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation rewiring degron network	0.25
p.G506R	SIDM01680	Non-Cancerous	GDSC	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation rewiring degron network	0.1944
p.G506R	SIDM01083	Oral Cavity Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	509:514	Mutation rewiring degron network	0.25
p.G506R	SIDM01083	Oral Cavity Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	511:516	Mutation rewiring degron network	0.1944
p.E77K	SIDM01699	Chondrosarcoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.25
p.E77K	ACH-000224	Non-Cancerous	CCLE	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.25
p.V74F	SW1990	pancreas	COSMIC	LSVHPE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.7068

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLHDC4

UniProt ID: Q8TBB5

Entrez ID: 54758

Protein name: Kelch domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KLHDC4 in