DegronMD

Uniprot ID: Q8TBB5

Source protein: Kelch domain-containing protein 4

Source gene: KLHDC4

Class: DEG_Kelch_Keap1_1

Location: 509:514

E3 ligase: KEAP1

DEGRON score: 0.8231

ASA_SCORE: 97.6667

COIL: 0.929

CONS_SCORE: 0.346

DSS_SCORE: 0.9896

HELIX: 0.0492

FCONS_SCORE: 0.8625

RIG_SCORE: 0.5971

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G513R	TCGA-AR-A0U4	BRCA	TCGA	DEDSGE	DEG_Kelch_Keap1_1	0.7568
p.E510K	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.591
p.E510D	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.5647
p.E510D	SIDM00544	Neuroblastoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.5647
p.E510D	SIDM00276	Biliary Tract Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.5647
p.E510D	SIDM00241	Breast Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.5647
p.E510D	SIDM00579	Neuroblastoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.5647
p.E510D	KYSE-180	oesophagus	COSMIC	DEDSGE	DEG_Kelch_Keap1_1	0.5647
p.E510D	GOTO	autonomic_ganglia	COSMIC	DEDSGE	DEG_Kelch_Keap1_1	0.5647
p.E510D	OCUB-M	breast	COSMIC	DEDSGE	DEG_Kelch_Keap1_1	0.5647
p.E510D	ETK-1	biliary_tract	COSMIC	DEDSGE	DEG_Kelch_Keap1_1	0.5647
p.D508N	SIDM00676	Bladder Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.3056
p.G506V	TCGA-D3-A2J6	SKCM	TCGA	DEDSGE	DEG_Kelch_Keap1_1	0.25
p.G506R	SIDM01114	Non-Cancerous	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.25
p.G506R	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.25
p.G506R	SIDM01680	Non-Cancerous	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.25
p.G506R	SIDM01083	Oral Cavity Carcinoma	GDSC	DEDSGE	DEG_Kelch_Keap1_1	0.25
p.A518V	TCGA-BT-A3PH	BLCA	TCGA	DEDSGE	DEG_Kelch_Keap1_1	0.2222
p.E504A	TCGA-AP-A054	UCEC	TCGA	DEDSGE	DEG_Kelch_Keap1_1	0.1944

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBB5	Kelch domain-containing protein 4	DEG_Kelch_Keap1_1	509:514	DEDSGE	KEAP1	0.8231	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons