DegronMD

Uniprot ID: Q8TBB5

Source protein: Kelch domain-containing protein 4

Source gene: KLHDC4

Class: LIG_APCC_ABBA_1

Location: 69:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7822

ASA_SCORE: 36.0667

COIL: 0.3575

CONS_SCORE: 0.3871

DSS_SCORE: 0.3702

HELIX: 0.0282

FCONS_SCORE: 0.6738

RIG_SCORE: 0.7169

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S70L	TCGA-55-8089	LUAD	TCGA	LSVHPE	LIG_APCC_ABBA_1	0.6556
p.S70L	DO23690	LUAD	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.6556
p.P73S	TCGA-A2-A0D2	BRCA	TCGA	LSVHPE	LIG_APCC_ABBA_1	0.5641
p.P73S	TCGA-EE-A3AF	SKCM	TCGA	LSVHPE	LIG_APCC_ABBA_1	0.5641
p.P73S	DO6072	BRCA	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.5641
p.P73S	DO37911	SKCM	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.5641
p.E74D	TCGA-A5-A0G2	UCEC	TCGA	LSVHPE	LIG_APCC_ABBA_1	0.5647
p.E74D	DO41235	UCEC	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.5647
p.D76Y	TCGA-AX-A2HC	UCEC	TCGA	LSVHPE	LIG_APCC_ABBA_1	0.2778
p.D76Y	DO41572	UCEC	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.2778
p.S62T	TCGA-AZ-6601	COAD	TCGA	LSVHPE	LIG_APCC_ABBA_1	0.5833
p.S62T	DO8119	COAD	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.5833
p.P73L	TCGA-EE-A3AF	SKCM	TCGA	LSVHPE	LIG_APCC_ABBA_1	0.6471
p.P73L	DO37911	SKCM	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.6471
p.A67V	DO219010	BLCA	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.2778
p.A67V	DO223286	UCEC	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.2778
p.Q66K	DO229009	LICA	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.25
p.F81L	DO220851	MELA	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.1389
p.Q72E	DO32831	PACA	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.6744
p.G82W	DO42472	UCEC	ICGC	LSVHPE	LIG_APCC_ABBA_1	0.1111
p.L69V	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	0.5654
p.L69V	SIDM01036	Plasma Cell Myeloma	GDSC	LSVHPE	LIG_APCC_ABBA_1	0.5654
p.L69V	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	0.5654
p.L69V	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	0.5654
p.L69V	SIDM01681	Non-Cancerous	GDSC	LSVHPE	LIG_APCC_ABBA_1	0.5654
p.L69V	SIDM01042	Breast Carcinoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	0.5654
p.E77K	SIDM01699	Chondrosarcoma	GDSC	LSVHPE	LIG_APCC_ABBA_1	0.25
p.E77K	ACH-000224	Non-Cancerous	CCLE	LSVHPE	LIG_APCC_ABBA_1	0.25
p.V74F	SW1990	pancreas	COSMIC	LSVHPE	LIG_APCC_ABBA_1	0.7068

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSVHPE

Degron related mutations and impact score

Drug responses associated with KLHDC4 mutations

All proteins holding degron of LSVHPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBB5	Kelch domain-containing protein 4	LIG_APCC_ABBA_1	69:74	LSVHPE	APC,CDC20,FZR1	0.7822	More...