DegronMD

Uniprot ID: Q8TBB5

Source protein: Kelch domain-containing protein 4

Source gene: KLHDC4

Class: DEG_SCF_TRCP1_1

Location: 511:516

E3 ligase: BTRC

DEGRON score: 0.8231

ASA_SCORE: 98.2167

COIL: 0.9375

CONS_SCORE: 0.3325

DSS_SCORE: 0.9967

HELIX: 0.0453

FCONS_SCORE: 0.819

RIG_SCORE: 0.5778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E504A	TCGA-AP-A054	UCEC	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.1389
p.G513R	TCGA-AR-A0U4	BRCA	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.7568
p.A518V	TCGA-BT-A3PH	BLCA	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.2778
p.G506V	TCGA-D3-A2J6	SKCM	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.1944
p.E515K	TCGA-EB-A5UN	SKCM	TCGA	DSGEES	DEG_SCF_TRCP1_1	0.591
p.D508N	SIDM00676	Bladder Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	0.25
p.G506R	SIDM01114	Non-Cancerous	GDSC	DSGEES	DEG_SCF_TRCP1_1	0.1944
p.G506R	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	0.1944
p.G506R	SIDM01680	Non-Cancerous	GDSC	DSGEES	DEG_SCF_TRCP1_1	0.1944
p.G506R	SIDM01083	Oral Cavity Carcinoma	GDSC	DSGEES	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBB5	Kelch domain-containing protein 4	DEG_SCF_TRCP1_1	511:516	DSGEES	BTRC	0.8231	More...
Q99457	Nucleosome assembly protein 1-like 3	DEG_SCF_TRCP1_1	28:33	DSGEES	BTRC	0.8883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons