DegronMD - Q8TB72(PUM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T636K	TCGA-14-1396	GBM	TCGA	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7306
p.T636K	DO11429	GBM	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7306
p.G351W	TCGA-44-A4SS	LUAD	TCGA	PPQY	ITCH	342:345	Mutation rewiring degron network	0.1667
p.S686R	TCGA-64-5781	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1667
p.P638L	TCGA-A5-A0G2	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.6471
p.P638L	DO41235	UCEC	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.6471
p.P627S	TCGA-AA-A01R	COAD	TCGA	PSQTPGHS	DEG_SCF_FBW7_1	627:634	Mutation altering degron motif	0.6752
p.P627S	DO7934	COAD	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	627:634	Mutation altering degron motif	0.6752
p.R110Q	TCGA-AN-A046	BRCA	TCGA	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1111
p.R110Q	DO1285	BRCA	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1111
p.R110Q	SIDM00677	Colorectal Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1111
p.P103L	TCGA-AR-A24H	BRCA	TCGA	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.3056
p.P103L	DO3043	BRCA	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.3056
p.S647L	TCGA-C5-A1BI	CESC	TCGA	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation rewiring degron network	0.1389
p.S647L	DO48372	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation rewiring degron network	0.1389
p.S647L	DO44305	CESC	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation rewiring degron network	0.1389
p.P619A	TCGA-DK-AA74	BLCA	TCGA	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	602:615	Mutation rewiring degron network	0.2222
p.P619A	TCGA-DK-AA74	BLCA	TCGA	PSQTPGHS	DEG_SCF_FBW7_1	627:634	Mutation rewiring degron network	0.1111
p.P619A	DO219011	BLCA	ICGC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	602:615	Mutation rewiring degron network	0.2222
p.P619A	DO219011	BLCA	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	627:634	Mutation rewiring degron network	0.1111
p.K106T	TCGA-EO-A22R	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation substituting flanking lysine	0.3333
p.P354S	TCGA-GN-A26C	SKCM	TCGA	PPQY	ITCH	342:345	Mutation rewiring degron network	0.0833
p.A104V	TCGA-MA-AA42	CESC	TCGA	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2778
p.A104V	DO219724	CESC	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2778
p.G668E	TCGA-RW-A67V	PCPG	TCGA	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1111
p.V98I	TCGA-VQ-A8P2	STAD	TCGA	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.7076
p.V98I	DO51761	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.7076
p.D96Y	DO477	BLCA	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2778
p.Q680E	DO224968	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.6744
p.Q680E	DO227838	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.6744
p.S634P	DO228321	BRCA	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	627:634	Mutation altering degron motif	0.6752
p.F635L	DO1132	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.6981
p.D112N	DO1932	BRCA	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0556
p.N637S	DO3686	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7069
p.R674Q	DO222798	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.F687Y	DO234234	ESAD	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation blocking phosphorylation signal	0.5833
p.D670G	DO234459	ESAD	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1667
p.T636M	DO48296	ESCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7423
p.T636M	SIDM00999	Bladder Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7423
p.T636M	ACH-000973	Bladder Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7423
p.T636M	639-V	urinary tract	COSMIC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7423
p.E633D	DO219648	KIRP	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	627:634	Mutation altering degron motif	0.6758
p.P637T	DO228948	LICA	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7031
p.Q348K	DO228986	LICA	ICGC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.25
p.Q348K	DO229045	LICA	ICGC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.25
p.A104D	DO228986	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2778
p.P637Q	DO229038	LICA	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7035
p.S592Y	DO229037	LICA	ICGC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	602:615	Mutation blocking phosphorylation signal	0.5
p.A354S	DO50861	LICA	ICGC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.0833
p.F678L	DO45281	LIRI	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.6981
p.S630R	DO23740	LUAD	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	627:634	Mutation altering degron motif	0.7427
p.R103T	DO26894	LUSC	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.3056
p.E677Q	DO26442	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.6744
p.E670Q	DO49085	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1667
p.P636L	DO222423	MELA	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7582
p.P636L	DO37425	SKCM	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation altering degron motif	0.7582
p.P349L	DO222843	MELA	ICGC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.2222
p.P103A	DO50657	ORCA	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.3056
p.G612A	DO218280	ORCA	ICGC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	602:615	Mutation altering degron motif	0.754
p.V98L	DO46458	OV	ICGC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.6765
p.G335A	DO32207	OV	ICGC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.1389
p.N342S	DO36305	PRAD	ICGC	PPQY	ITCH	342:345	Mutation altering degron motif	0.7069
p.P341L	DO229208	THCA	ICGC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.3056
p.S648F	DO229240	THCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	635:640	Mutation rewiring degron network	0.1111
p.M679I	DO41686	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7618
p.A355T	DO41542	UCEC	ICGC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.0556
p.I688V	DO41999	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1111
p.V348I	SIDM00590	Oral Cavity Carcinoma	GDSC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.25
p.V348I	HSC-2	upper aerodigestive tract	COSMIC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.25
p.G606R	SIDM00254	Neuroblastoma	GDSC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	602:615	Mutation altering degron motif	0.6457
p.G606R	ACH-002283	Neuroblastoma	CCLE	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	602:615	Mutation altering degron motif	0.6457
p.G606R	NB5	autonomic ganglia	COSMIC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	602:615	Mutation altering degron motif	0.6457
p.G91C	SIDM00324	Neuroblastoma	GDSC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1389
p.G91C	ACH-001674	Neuroblastoma	CCLE	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1389
p.G91C	TGW	autonomic ganglia	COSMIC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1389
p.Q92R	EN	endometrium	COSMIC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1667
p.Q348H	MC116	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.25
p.R679C	GI-ME-N	autonomic ganglia	COSMIC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.8301
p.G102D	SNU-C5	large intestine	COSMIC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.7198
p.R337C	SU8686	pancreas	COSMIC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.1944
p.R669G	RERF-LC-Sq1	lung	COSMIC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1389
p.A111G	NCI-H2081	lung	COSMIC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0833
p.Q336P	HT	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.1667
p.E598D	AMO-1	haematopoietic and lymphoid tissue	COSMIC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	602:615	Mutation rewiring degron network	0.2222
p.P106S	U-2-OS	bone	COSMIC	VLSSS	DEG_SPOP_SBC_1	98:102	Mutation substituting flanking lysine	0.3333
p.A354V	SW48	large intestine	COSMIC	PPQY	ITCH	342:345	Mutation rewiring degron network	0.0833
p.E677D	AMO-1	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.6758

Kaplan plot for PUM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PUM2

UniProt ID: Q8TB72

Entrez ID: 23369

Protein name: Pumilio homolog 2 (Pumilio-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PUM2 in