DegronMD

Uniprot ID: Q8TB72

Source protein: Pumilio homolog 2

Source gene: PUM2

Class: DEG_ODPH_VHL_1

Location: 602:615

E3 ligase: VHL

DEGRON score: 0.9919

ASA_SCORE: 44.5429

COIL: 0.882

CONS_SCORE: 0.2905

DSS_SCORE: 0.402

HELIX: 0.0566

FCONS_SCORE: 1.0169

RIG_SCORE: 0.6643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P619A	TCGA-DK-AA74	BLCA	TCGA	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	0.2222
p.P619A	DO219011	BLCA	ICGC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	0.2222
p.S592Y	DO229037	LICA	ICGC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	0.5
p.G612A	DO218280	ORCA	ICGC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	0.754
p.G606R	SIDM00254	Neuroblastoma	GDSC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	0.6457
p.G606R	ACH-002283	Neuroblastoma	CCLE	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	0.6457
p.G606R	NB5	autonomic_ganglia	COSMIC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	0.6457
p.E598D	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPIGQPFYNSLGF	DEG_ODPH_VHL_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TB72	Pumilio homolog 2	DEG_ODPH_VHL_1	602:615	LAPIGQPFYNSLGF	VHL	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons