DegronMD

Uniprot ID: Q8TB72

Source protein: Pumilio homolog 2

Source gene: PUM2

Class: DEG_SCF_FBW7_1

Location: 627:634

E3 ligase: FBXW7

DEGRON score: 0.936

ASA_SCORE: 62.2625

COIL: 0.9171

CONS_SCORE: 0.2349

DSS_SCORE: 0.7156

HELIX: 0.0426

FCONS_SCORE: 0.6883

RIG_SCORE: 0.5494

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P627S	TCGA-AA-A01R	COAD	TCGA	PSQTPGHS	DEG_SCF_FBW7_1	0.6752
p.P627S	DO7934	COAD	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	0.6752
p.P619A	TCGA-DK-AA74	BLCA	TCGA	PSQTPGHS	DEG_SCF_FBW7_1	0.1111
p.P619A	DO219011	BLCA	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	0.1111
p.S634P	DO228321	BRCA	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	0.6752
p.E633D	DO219648	KIRP	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	0.6758
p.S630R	DO23740	LUAD	ICGC	PSQTPGHS	DEG_SCF_FBW7_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TB72	Pumilio homolog 2	DEG_SCF_FBW7_1	627:634	PSQTPGHS	FBXW7	0.936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons