DegronMD - Q7Z460(CLASP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N1274K	TCGA-22-5472	LUSC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.1111
p.A807V	TCGA-AA-3977	COAD	TCGA	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.0556
p.D1287N	TCGA-AA-A02R	COAD	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation altering degron motif	0.5821
p.A1272V	TCGA-AJ-A3BH	UCEC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.0556
p.S259A	TCGA-AP-A056	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.7588
p.S259A	DO43971	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.7588
p.P622H	TCGA-AX-A06F	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.2222
p.P622H	DO41752	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.2222
p.K1278R	TCGA-AX-A2HC	UCEC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation blocking ubiquitination signal	0.6667
p.A1280T	TCGA-BS-A0UV	UCEC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.2778
p.A1280T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.2778
p.A1280T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.2778
p.A1280T	ACH-000920	Leukemia	CCLE	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.2778
p.A1280T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.2778
p.P785L	TCGA-CW-5580	KIRC	TCGA	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1111
p.A608V	TCGA-DF-A2KU	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1667
p.A608V	DO223286	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1667
p.N1274D	TCGA-DI-A1BU	UCEC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.1111
p.R267L	TCGA-EE-A2MM	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.R267L	DO37770	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.S257T	TCGA-FW-A3TV	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.6005
p.S257T	DO38159	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.6005
p.S257F	TCGA-GN-A26C	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.7982
p.S257F	DO37782	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.7982
p.T620M	TCGA-NH-A5IV	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.2778
p.T620M	DO52750	CMDI	ICGC	VSSSS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.2778
p.T620M	DO49095	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.2778
p.R1289W	DO2737	BRCA	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.3056
p.R786K	DO222656	BTCA	ICGC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1389
p.A799V	DO7828	COAD	ICGC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.2778
p.R1277W	DO8634	COAD	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.1944
p.E789Q	DO222705	ESCA	ICGC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.2222
p.R1277Q	DO233737	GACA	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.1944
p.Y788C	DO233748	GACA	ICGC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1944
p.D802N	DO14566	HNSC	ICGC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1944
p.P252T	DO229029	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.25
p.A255D	DO229032	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.7793
p.K1278E	DO23907	LUAD	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation blocking ubiquitination signal	0.6667
p.A803S	DO26949	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1667
p.K1278N	DO26454	LUSC	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation blocking ubiquitination signal	0.6667
p.A1280V	DO38006	SKCM	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.2778
p.S618L	DO38727	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	614:618	Mutation altering degron motif	0.7667
p.P790S	DO51766	STAD	ICGC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.25
p.P790S	DO43907	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.25
p.D798G	DO47869	STAD	ICGC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation blocking phosphorylation signal	0.75
p.T1288M	DO42113	UCEC	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation altering degron motif	0.7423
p.S785A	SIDM00845	Burkitt's Lymphoma	GDSC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1111
p.S785A	SIDM00461	Acute Myeloid Leukemia	GDSC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.1111
p.A1280S	SIDM00098	Mesothelioma	GDSC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.2778
p.A1280S	H2731	pleura	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.2778
p.S266Y	SIDM01588	Endometrial Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1389
p.S266Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1389
p.G1289R	ACH-000338	Lymphoma	CCLE	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.3056
p.E1274Q	ACH-000752	Lung Cancer	CCLE	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.1111
p.E1274Q	NCI-H196	lung	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.1111
p.S617F	ACH-000777	Esophageal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	614:618	Mutation altering degron motif	0.7982
p.E1280Q	NCI-H196	lung	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.2778
p.V806A	22RV1	prostate	COSMIC	VLSTS	DEG_SPOP_SBC_1	793:797	Mutation rewiring degron network	0.0833
p.E1282Q	NCI-H196	lung	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation altering degron motif	0.6744
p.E1281Q	NCI-H196	lung	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	1282:1288	Mutation rewiring degron network	0.3056

Kaplan plot for CLASP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLASP1

UniProt ID: Q7Z460

Entrez ID: 23332

Protein name: CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLASP1 in