DegronMD

Uniprot ID: Q7Z460

Source protein: CLIP-associating protein 1

Source gene: CLASP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 1282:1288

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8558

ASA_SCORE: 78.2571

COIL: 0.4529

CONS_SCORE: 0.2405

DSS_SCORE: 0.3587

HELIX: 0.4836

FCONS_SCORE: 0.9624

RIG_SCORE: 0.8477

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1274K	TCGA-22-5472	LUSC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D1287N	TCGA-AA-A02R	COAD	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.5821
p.A1272V	TCGA-AJ-A3BH	UCEC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.K1278R	TCGA-AX-A2HC	UCEC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.6667
p.A1280T	TCGA-BS-A0UV	UCEC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A1280T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A1280T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A1280T	ACH-000920	Leukemia	CCLE	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A1280T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.N1274D	TCGA-DI-A1BU	UCEC	TCGA	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1289W	DO2737	BRCA	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R1277W	DO8634	COAD	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R1277Q	DO233737	GACA	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.K1278E	DO23907	LUAD	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.6667
p.K1278N	DO26454	LUSC	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.6667
p.A1280V	DO38006	SKCM	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T1288M	DO42113	UCEC	ICGC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.7423
p.A1280S	SIDM00098	Mesothelioma	GDSC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A1280S	H2731	pleura	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G1289R	ACH-000338	Lymphoma	CCLE	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E1274Q	ACH-000752	Lung Cancer	CCLE	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1274Q	NCI-H196	lung	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1280Q	NCI-H196	lung	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E1282Q	NCI-H196	lung	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.6744
p.E1281Q	NCI-H196	lung	COSMIC	KEAVFDD	LIG_APCC_ABBAyCdc20_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KEAVFDD

Degron related mutations and impact score

Drug responses associated with CLASP1 mutations

All proteins holding degron of KEAVFDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z460	CLIP-associating protein 1	LIG_APCC_ABBAyCdc20_2	1282:1288	KEAVFDD	APC,CDC20,FZR1	0.8558	More...