DegronMD - Q8N8S7(ENAH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A484V	TCGA-AD-6964	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.5825
p.A484V	DO8360	COAD	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.5825
p.A484V	DO230309	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.5825
p.A484T	TCGA-C5-A1M7	CESC	TCGA	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7139
p.A484T	DO48981	CESC	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7139
p.A484S	TCGA-EJ-A65F	PRAD	TCGA	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7588
p.A484S	DO51315	PRAD	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.7588
p.E478K	TCGA-EK-A3GJ	CESC	TCGA	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.E478K	DO49962	CESC	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.1667
p.K483N	TCGA-FS-A1ZB	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.75
p.K483N	DO37886	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation blocking ubiquitination signal	0.75
p.T487K	DO229015	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.8417
p.P289T	DO229025	LICA	ICGC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.0556
p.P289T	DO229026	LICA	ICGC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.0556
p.P493H	DO229037	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation blocking phosphorylation signal	0.6389
p.T493K	DO229045	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation blocking phosphorylation signal	0.6389
p.P492L	DO229051	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2222
p.S284F	DO220908	MELA	ICGC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.1944
p.P288S	DO229459	SKCA	ICGC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.0833
p.E274G	DO229211	THCA	ICGC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation altering degron motif	0.6087
p.A267T	SIDM00499	Prostate Carcinoma	GDSC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.1667
p.A267T	22RV1	prostate	COSMIC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.1667
p.D283N	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.2222
p.S266T	SIDM01194	Hepatocellular Carcinoma	GDSC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation blocking phosphorylation signal	0.5833
p.S266T	SNU-449	liver	COSMIC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation blocking phosphorylation signal	0.5833
p.A271V	SIDM00537	Colorectal Carcinoma	GDSC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.2778
p.P492S	SIDM01735	Biliary Tract Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation rewiring degron network	0.2222
p.S285T	ACH-000420	Liver Cancer	CCLE	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.1667
p.A286T	ACH-000956	Prostate Cancer	CCLE	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.1389
p.E280A	ACH-000990	Endometrial/Uterine Cancer	CCLE	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.3056
p.E280A	ACH-001669	Leukemia	CCLE	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.3056
p.E280A	ACH-002238	Leukemia	CCLE	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.3056
p.R279I	ACH-001369	Ovarian Cancer	CCLE	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation altering degron motif	0.8102
p.S270T	SNU-449	liver	COSMIC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.25
p.S486L	MDA-MB-453	breast	COSMIC	ASSTS	DEG_SPOP_SBC_1	484:488	Mutation altering degron motif	0.8778
p.E265A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation blocking phosphorylation signal	0.5556
p.A271T	22RV1	prostate	COSMIC	VETPLNS	DEG_SCF_FBW7_1	273:279	Mutation rewiring degron network	0.2778

Kaplan plot for ENAH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ENAH

UniProt ID: Q8N8S7

Entrez ID: 55740

Protein name: Protein enabled homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ENAH in