DegronMD

Uniprot ID: Q8N8S7

Source protein: Protein enabled homolog

Source gene: ENAH

Class: DEG_SCF_FBW7_1

Location: 273:279

E3 ligase: FBXW7

DEGRON score: 0.9264

ASA_SCORE: 93.5857

COIL: 0.8896

CONS_SCORE: 0.3625

DSS_SCORE: 0.5953

HELIX: 0.0636

FCONS_SCORE: 0.9888

RIG_SCORE: 0.6684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P289T	DO229025	LICA	ICGC	VETPLNS	DEG_SCF_FBW7_1	0.0556
p.P289T	DO229026	LICA	ICGC	VETPLNS	DEG_SCF_FBW7_1	0.0556
p.S284F	DO220908	MELA	ICGC	VETPLNS	DEG_SCF_FBW7_1	0.1944
p.P288S	DO229459	SKCA	ICGC	VETPLNS	DEG_SCF_FBW7_1	0.0833
p.E274G	DO229211	THCA	ICGC	VETPLNS	DEG_SCF_FBW7_1	0.6087
p.A267T	SIDM00499	Prostate Carcinoma	GDSC	VETPLNS	DEG_SCF_FBW7_1	0.1667
p.A267T	22RV1	prostate	COSMIC	VETPLNS	DEG_SCF_FBW7_1	0.1667
p.D283N	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	VETPLNS	DEG_SCF_FBW7_1	0.2222
p.S266T	SIDM01194	Hepatocellular Carcinoma	GDSC	VETPLNS	DEG_SCF_FBW7_1	0.5833
p.S266T	SNU-449	liver	COSMIC	VETPLNS	DEG_SCF_FBW7_1	0.5833
p.A271V	SIDM00537	Colorectal Carcinoma	GDSC	VETPLNS	DEG_SCF_FBW7_1	0.2778
p.S285T	ACH-000420	Liver Cancer	CCLE	VETPLNS	DEG_SCF_FBW7_1	0.1667
p.A286T	ACH-000956	Prostate Cancer	CCLE	VETPLNS	DEG_SCF_FBW7_1	0.1389
p.E280A	ACH-000990	Endometrial/Uterine Cancer	CCLE	VETPLNS	DEG_SCF_FBW7_1	0.3056
p.E280A	ACH-001669	Leukemia	CCLE	VETPLNS	DEG_SCF_FBW7_1	0.3056
p.E280A	ACH-002238	Leukemia	CCLE	VETPLNS	DEG_SCF_FBW7_1	0.3056
p.R279I	ACH-001369	Ovarian Cancer	CCLE	VETPLNS	DEG_SCF_FBW7_1	0.8102
p.S270T	SNU-449	liver	COSMIC	VETPLNS	DEG_SCF_FBW7_1	0.25
p.E265A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VETPLNS	DEG_SCF_FBW7_1	0.5556
p.A271T	22RV1	prostate	COSMIC	VETPLNS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N8S7	Protein enabled homolog	DEG_SCF_FBW7_1	273:279	VETPLNS	FBXW7	0.9264	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons