DegronMD

Uniprot ID: Q9Y2I7

Source protein: 1-phosphatidylinositol 3-phosphate 5-kinase

Source gene: PIKFYVE

Class: DEG_SPOP_SBC_1

Location: 1176:1180

E3 ligase: SPOP

DEGRON score: 0.9955

ASA_SCORE: 73.46

COIL: 0.8726

CONS_SCORE: 0.2483

DSS_SCORE: 0.6956

HELIX: 0.0722

FCONS_SCORE: 1.1067

RIG_SCORE: 0.5405

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1174R	TCGA-66-2759	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.2778
p.K1174R	DO27326	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.A1176T	TCGA-F4-6856	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	0.7139
p.A1176T	DO9114	COAD	ICGC	ASSTS	DEG_SPOP_SBC_1	0.7139
p.E1189Q	DO225226	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0833
p.Q1183K	DO229010	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.25
p.Q1183K	DO229013	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.25
p.Q1183K	DO229016	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.25
p.Q1183K	DO229003	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.25
p.Q1183K	DO229005	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.25
p.D1175Y	DO229035	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.3056
p.S1186I	DO229006	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1667
p.K1174M	DO23250	LINC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.N1188T	SIDM00009	Acute Myeloid Leukemia	GDSC	ASSTS	DEG_SPOP_SBC_1	0.1111
p.N1188T	ACH-002390	Leukemia	CCLE	ASSTS	DEG_SPOP_SBC_1	0.1111
p.N1188T	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.1111
p.S1178G	SIDM01435	Hepatocellular Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.6993
p.S1178G	ACH-000686	Liver Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.6993

Drug responses associated with PIKFYVE mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00918	OV\|ovary	p.R572Q (No)	GDSC	YM201636	14.9278
SIDM00889	CESC\|cervix	p.E829fs*1 (No)	GDSC	YM201636	1.7478
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A1827T (No)	GDSC	YM201636	1.5959
SIDM01029	ESCA\|oesophagus	p.V2051L (No)	GDSC	YM201636	6.3411
SIDM00213	THCA\|thyroid	p.P1521H (No)	GDSC	YM201636	75.4698
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R1881S (No)	GDSC	YM201636	10.9164
SIDM00499	PRAD\|prostate	p.I229V (No)	GDSC	YM201636	3.5303
SIDM00967	OV\|ovary	p.P818S (No)	GDSC	YM201636	8.4389
SIDM00754	LUAD\|lung_NSCLC_adenocarcinoma	p.I667M (No)	GDSC	YM201636	69.5696
SIDM00901	UCEC\|endometrium	p.A512V (No)	GDSC	YM201636	6.2194
SIDM00957	COREAD\|large_intestine	p.L2094F (No)	GDSC	YM201636	61.6263
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.R176H (No)	GDSC	YM201636	4.1383
SIDM00859	DLBC\|B_cell_lymphoma	p.P77S (No)	GDSC	YM201636	0.4883
SIDM00877	BRCA\|breast	p.H1364D (No)	GDSC	YM201636	3.335
SIDM00620	LGG\|glioma	p.T1764N (No)	GDSC	YM201636	4.7794
SIDM00250	ESCA\|oesophagus	p.T1564A (No)	GDSC	YM201636	40.7615
SIDM00527	COREAD\|large_intestine	p.V337F (No)	GDSC	YM201636	10.9964
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A901G (No)	GDSC	YM201636	4.6072
SIDM01007	ALL\|lymphoblastic_leukemia	p.Y46H (No)	GDSC	YM201636	2.4259
SIDM01007	ALL\|lymphoblastic_leukemia	p.A878S (No)	GDSC	YM201636	2.4259
SIDM01007	ALL\|lymphoblastic_leukemia	p.F1606L (No)	GDSC	YM201636	2.4259
SIDM00664	PAAD\|pancreas	p.V652I (No)	GDSC	YM201636	126.841
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.V902F (No)	GDSC	YM201636	68.7086
SIDM00466	OV\|ovary	p.M1473L (No)	GDSC	YM201636	2.1923
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.Q293P (No)	GDSC	YM201636	0.9244
SIDM00214	COREAD\|large_intestine	p.A691V (No)	GDSC	YM201636	2.354
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.P1593R (No)	GDSC	YM201636	1.9314
SIDM01045	UCEC\|endometrium	p.K162N (No)	GDSC	YM201636	5.7846
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.P450S (No)	GDSC	YM201636	56.3953
SIDM00256	NB\|neuroblastoma	p.K1446E (No)	GDSC	YM201636	3.3857
SIDM00217	COREAD\|large_intestine	p.A106V (No)	GDSC	YM201636	5.0645
SIDM00681	COREAD\|large_intestine	p.E1793V (No)	GDSC	YM201636	4.7949
SIDM00839	COREAD\|large_intestine	p.L2094F (No)	GDSC	YM201636	28.3603
SIDM00216	COREAD\|large_intestine	p.A513T (No)	GDSC	YM201636	1.5906
SIDM00216	COREAD\|large_intestine	p.R1560H (No)	GDSC	YM201636	1.5906
SIDM00282	COREAD\|large_intestine	p.Y1026H (No)	GDSC	YM201636	21.7007
SIDM00282	COREAD\|large_intestine	p.S1034Y (No)	GDSC	YM201636	21.7007
SIDM00637	DLBC\|B_cell_lymphoma	p.S1474F (No)	GDSC	YM201636	2.0845
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E894V (No)	GDSC	YM201636	3.7282
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I1427V (No)	GDSC	YM201636	2.0036
SIDM00257	NB\|neuroblastoma	p.A965G (No)	GDSC	YM201636	2.6281
SIDM00382	GBM\|glioma	p.D1604fs*15 (No)	GDSC	YM201636	13.1669
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.M859V (No)	GDSC	YM201636	10.5899
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.E920* (No)	GDSC	YM201636	10.5899
SIDM00789	COREAD\|large_intestine	p.R375C (No)	GDSC	YM201636	10.4792
SIDM00789	COREAD\|large_intestine	p.I1898F (No)	GDSC	YM201636	10.4792
SIDM00273	LGG\|glioma	p.G460R (No)	GDSC	YM201636	6.0988
SIDM00487	COREAD\|large_intestine	p.D12G (No)	GDSC	YM201636	4.5961
SIDM01169	OV\|ovary	p.R1401H (No)	GDSC	YM201636	26.7747
SIDM00255	NB\|neuroblastoma	p.V1279L (No)	GDSC	YM201636	5.2676
SIDM00114	MESO\|mesothelioma	p.S628L (No)	GDSC	YM201636	3.5121
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A1674T (No)	GDSC	YM201636	5.4175
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.S514C (No)	GDSC	YM201636	7.092
SIDM00127	HNSC\|head_and_neck	p.R1546L (No)	GDSC	YM201636	10.6644
SIDM01138	PAAD\|pancreas	p.S639L (No)	GDSC	YM201636	13.7477
SIDM00285	NB\|neuroblastoma	p.T1571N (No)	GDSC	YM201636	5.2611
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E1654D (No)	GDSC	YM201636	24.1933
SIDM00581	GBM\|glioma	p.P584L (No)	GDSC	YM201636	7.3773
SIDM01259	ALL\|lymphoblastic_leukemia	p.R1284H (No)	GDSC	YM201636	1.5408
SIDM00537	COREAD\|large_intestine	p.R54C (No)	GDSC	YM201636	3.208
SIDM00537	COREAD\|large_intestine	p.V290A (No)	GDSC	YM201636	3.208
SIDM00537	COREAD\|large_intestine	p.A1378V (No)	GDSC	YM201636	3.208
SIDM01246	NB\|neuroblastoma	p.H536P (No)	GDSC	YM201636	4.5459
SIDM00384	DLBC\|B_cell_lymphoma	p.L419M (No)	GDSC	YM201636	5.5032
SIDM00837	COREAD\|large_intestine	p.R379I (No)	GDSC	YM201636	21.8994
SIDM00238	OV\|ovary	p.S88P (No)	GDSC	YM201636	9.4778
SIDM00238	OV\|ovary	p.M605T (No)	GDSC	YM201636	9.4778
SIDM00238	OV\|ovary	p.Y1650H (No)	GDSC	YM201636	9.4778
SIDM00113	KIRC\|kidney	p.Q331H (No)	GDSC	YM201636	24.1926
SIDM00817	KIRC\|kidney	p.T1205A (No)	GDSC	YM201636	38.0465
SIDM00852	LGG\|glioma	p.Q987H (No)	GDSC	YM201636	24.2634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1446:1450	ASSTS	SPOP	0.9991	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	578:582	ASSTS	SPOP	0.9737	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1755:1759	ASSTS	SPOP	0.6619	More...
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	630:634	ASSTS	SPOP	0.9397	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	85:89	ASSTS	SPOP	0.9434	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1352:1356	ASSTS	SPOP	0.9983	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	148:152	ASSTS	SPOP	0.9958	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	2:6	ASSTS	SPOP	0.9282	More...
Q04724	Transducin-like enhancer protein 1	DEG_SPOP_SBC_1	294:298	ASSTS	SPOP	0.9961	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	180:184	ASSTS	SPOP	0.9864	More...
Q5T5U3	Rho GTPase-activating protein 21	DEG_SPOP_SBC_1	791:795	ASSTS	SPOP	0.9947	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	520:524	ASSTS	SPOP	0.8668	More...
Q6ZUJ8	Phosphoinositide 3-kinase adapter protein 1	DEG_SPOP_SBC_1	723:727	ASSTS	SPOP	0.9991	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1125:1129	ASSTS	SPOP	0.9989	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	255:259	ASSTS	SPOP	0.9466	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6830:6834	ASSTS	SPOP	0.963	More...
Q8IZR5	CKLF-like MARVEL transmembrane domain-containing protein 4	DEG_SPOP_SBC_1	14:18	ASSTS	SPOP	0.9523	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	452:456	ASSTS	SPOP	0.9768	More...
Q8N8S7	Protein enabled homolog	DEG_SPOP_SBC_1	484:488	ASSTS	SPOP	0.9828	More...
Q8TB72	Pumilio homolog 2	DEG_SPOP_SBC_1	676:680	ASSTS	SPOP	0.9986	More...
Q96JM7	Lethal	DEG_SPOP_SBC_1	5:9	ASSTS	SPOP	0.9955	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	98:102	ASSTS	SPOP	0.9954	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	185:189	ASSTS	SPOP	0.97	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	525:529	ASSTS	SPOP	0.908	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1176:1180	ASSTS	SPOP	0.9955	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	158:162	ASSTS	SPOP	0.9526	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	227:231	ASSTS	SPOP	0.9062	More...
Q5RHP9	Glutamate-rich protein 3	DEG_SPOP_SBC_1	580:584	ASSTS	SPOP	0.9566	More...
Q99457	Nucleosome assembly protein 1-like 3	DEG_SPOP_SBC_1	23:27	ASSTS	SPOP	0.5181	More...
Q92628	Uncharacterized protein KIAA0232	DEG_SPOP_SBC_1	1366:1370	ASSTS	SPOP	0.9835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSTS

Degron related mutations and impact score

Drug responses associated with PIKFYVE mutations

All proteins holding degron of ASSTS