DegronMD - Q92628(KIAA0232)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1379V	TCGA-18-3421	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.0833
p.G1379V	DO27652	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.0833
p.G301W	TCGA-55-6981	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.2778
p.G301W	DO24265	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.2778
p.L306F	TCGA-A1-A0SN	BRCA	TCGA	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.L306F	DO4299	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.E266A	TCGA-BS-A0UF	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation rewiring degron network	0.1111
p.E266A	DO41488	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation rewiring degron network	0.1111
p.H244Y	TCGA-CM-4746	COAD	TCGA	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation rewiring degron network	0.0556
p.H244Y	DO7882	COAD	ICGC	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation rewiring degron network	0.0556
p.Q922K	TCGA-D3-A2JC	SKCM	TCGA	DKENT	DEG_APCC_KENBOX_2	923:927	Mutation rewiring degron network	0.3056
p.Q922K	DO47578	SKCM	ICGC	DKENT	DEG_APCC_KENBOX_2	923:927	Mutation rewiring degron network	0.3056
p.R1349T	TCGA-D3-A2JK	SKCM	TCGA	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.3056
p.R1349T	DO37619	SKCM	ICGC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.3056
p.Y934C	TCGA-D6-6823	HNSC	TCGA	DKENT	DEG_APCC_KENBOX_2	923:927	Mutation rewiring degron network	0.1389
p.Y934C	DO14222	HNSC	ICGC	DKENT	DEG_APCC_KENBOX_2	923:927	Mutation rewiring degron network	0.1389
p.E1372D	TCGA-EK-A3GK	CESC	TCGA	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.2778
p.E1372D	DO49964	CESC	ICGC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.2778
p.E1372D	DO229018	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.2778
p.R286H	TCGA-EO-A22R	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0833
p.R286H	DO42713	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0833
p.E254K	TCGA-FW-A3R5	SKCM	TCGA	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation altering degron motif	0.591
p.E254K	DO37406	SKCM	ICGC	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation altering degron motif	0.591
p.R1359H	DO228254	EOPC	ICGC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359H	DO228254	EOPC	ICGC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	DO228947	LICA	ICGC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	DO228947	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00373	Endometrial Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00373	Endometrial Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00582	Pancreatic Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00582	Pancreatic Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00555	Glioblastoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00555	Glioblastoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00002	Neuroblastoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00002	Neuroblastoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00394	Cervical Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00394	Cervical Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM01099	Neuroblastoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM01099	Neuroblastoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00687	Gastric Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00687	Gastric Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00235	Kidney Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00235	Kidney Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00365	Small Cell Lung Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00365	Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00324	Neuroblastoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00324	Neuroblastoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00368	Small Cell Lung Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00368	Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00986	Head and Neck Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00986	Head and Neck Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00604	Oral Cavity Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00604	Oral Cavity Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM01551	Gastric Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM01551	Gastric Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM00192	Colorectal Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM00192	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM01728	Endometrial Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM01728	Endometrial Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM01335	Kidney Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM01335	Kidney Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM01394	Kidney Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM01394	Kidney Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.R1359C	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1359C	SIDM01694	B-Lymphoblastic Leukemia	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1389
p.G1374V	DO228952	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.2222
p.E305D	DO23468	LINC	ICGC	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.E1348G	SIDM00969	Ovarian Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2778
p.S299F	SIDM01175	Other Sarcomas	GDSC	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7982
p.S299F	ACH-002309	Sarcoma	CCLE	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7982
p.S299F	SW684	soft tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7982
p.G262C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation rewiring degron network	0.2222
p.G262C	ACH-001669	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation rewiring degron network	0.2222
p.G262C	ACH-002238	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation rewiring degron network	0.2222
p.G262C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	254:258	Mutation rewiring degron network	0.2222
p.S1370L	SIDM00151	Ovarian Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation altering degron motif	0.7667
p.S1370L	ACH-000966	Ovarian Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation altering degron motif	0.7667
p.S1370L	IGROV-1	ovary	COSMIC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation altering degron motif	0.7667
p.G1378R	SIDM00252	Biliary Tract Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1111
p.G1378R	ACH-001861	Gallbladder Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1111
p.G1378R	TGBC1TKB	biliary tract	COSMIC	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation rewiring degron network	0.1111
p.S1367G	ACH-001786	Colon/Colorectal Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1366:1370	Mutation altering degron motif	0.5882

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA0232

UniProt ID: Q92628

Entrez ID: 9778

Protein name: Uncharacterized protein KIAA0232

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA0232 in