DegronMD

Uniprot ID: Q92628

Source protein: Uncharacterized protein KIAA0232

Source gene: KIAA0232

Class: DEG_SCF_TRCP1_1

Location: 1350:1355

E3 ligase: BTRC

DEGRON score: 0.9581

ASA_SCORE: 69.8

COIL: 0.7605

CONS_SCORE: 0.3027

DSS_SCORE: 0.4644

HELIX: 0.132

FCONS_SCORE: 0.9193

RIG_SCORE: 0.658

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1349T	TCGA-D3-A2JK	SKCM	TCGA	DSGAKS	DEG_SCF_TRCP1_1	0.3056
p.R1349T	DO37619	SKCM	ICGC	DSGAKS	DEG_SCF_TRCP1_1	0.3056
p.R1359H	DO228254	EOPC	ICGC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	DO228947	LICA	ICGC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00373	Endometrial Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00582	Pancreatic Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00555	Glioblastoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00002	Neuroblastoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00394	Cervical Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM01099	Neuroblastoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00687	Gastric Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00235	Kidney Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00365	Small Cell Lung Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00324	Neuroblastoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00368	Small Cell Lung Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00986	Head and Neck Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00604	Oral Cavity Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM01551	Gastric Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM00192	Colorectal Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM01728	Endometrial Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM01335	Kidney Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM01394	Kidney Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.R1359C	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2222
p.E1348G	SIDM00969	Ovarian Carcinoma	GDSC	DSGAKS	DEG_SCF_TRCP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGAKS

Degron related mutations and impact score

Drug responses associated with KIAA0232 mutations

All proteins holding degron of DSGAKS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92628	Uncharacterized protein KIAA0232	DEG_SCF_TRCP1_1	1350:1355	DSGAKS	BTRC	0.9581	More...