DegronMD

Uniprot ID: Q92628

Source protein: Uncharacterized protein KIAA0232

Source gene: KIAA0232

Class: DEG_APCC_KENBOX_2

Location: 923:927

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7191

ASA_SCORE: 87.54

COIL: 0.686

CONS_SCORE: 0.5782

DSS_SCORE: 0.3634

HELIX: 0.144

FCONS_SCORE: 0.6915

RIG_SCORE: 0.8525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q922K	TCGA-D3-A2JC	SKCM	TCGA	DKENT	DEG_APCC_KENBOX_2	0.3056
p.Q922K	DO47578	SKCM	ICGC	DKENT	DEG_APCC_KENBOX_2	0.3056
p.Y934C	TCGA-D6-6823	HNSC	TCGA	DKENT	DEG_APCC_KENBOX_2	0.1389
p.Y934C	DO14222	HNSC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31350	Ribonucleoside-diphosphate reductase subunit M2	DEG_APCC_KENBOX_2	29:33	DKENT	APC,CDC20,FZR1	0.9969	More...
Q8WZA2	Rap guanine nucleotide exchange factor 4	DEG_APCC_KENBOX_2	176:180	DKENT	APC,CDC20,FZR1	0.5031	More...
Q96MA1	Doublesex- and mab-3-related transcription factor B1	DEG_APCC_KENBOX_2	316:320	DKENT	APC,CDC20,FZR1	0.7162	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	923:927	DKENT	APC,CDC20,FZR1	0.7191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons