DegronMD

Uniprot ID: P31350

Source protein: Ribonucleoside-diphosphate reductase subunit M2

Source gene: RRM2

Class: DEG_APCC_KENBOX_2

Location: 29:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9969

ASA_SCORE: 95

COIL: 0.7846

CONS_SCORE: 0.2563

DSS_SCORE: 0.4838

HELIX: 0.194

FCONS_SCORE: 1.1902

RIG_SCORE: 0.6976

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A23T	TCGA-D1-A17A	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	0.6111
p.A23T	DO43875	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.6111
p.A26S	DO229026	LICA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.6944
p.G39W	DO229257	THCA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1667
p.V37I	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.2222
p.V37I	SIDM00232	Kidney Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.2222
p.S29L	SIDM00656	Burkitt's Lymphoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.7667
p.S29L	SIDM00641	Burkitt's Lymphoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.7667
p.M26L	SIDM00507	Other Solid Cancers	GDSC	DKENT	DEG_APCC_KENBOX_2	0.6944
p.P35H	SIDM00251	Gastric Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.2778
p.C34R	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.3056
p.V42A	ACH-000889	Myeloma	CCLE	DKENT	DEG_APCC_KENBOX_2	0.0833
p.L27F	NOS-1	bone	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31350	Ribonucleoside-diphosphate reductase subunit M2	DEG_APCC_KENBOX_2	29:33	DKENT	APC,CDC20,FZR1	0.9969	More...
Q8WZA2	Rap guanine nucleotide exchange factor 4	DEG_APCC_KENBOX_2	176:180	DKENT	APC,CDC20,FZR1	0.5031	More...
Q96MA1	Doublesex- and mab-3-related transcription factor B1	DEG_APCC_KENBOX_2	316:320	DKENT	APC,CDC20,FZR1	0.7162	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	923:927	DKENT	APC,CDC20,FZR1	0.7191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons