DegronMD - Q8WZA2(RAPGEF4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R190C	TCGA-B5-A1MR	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.0556
p.R190C	TCGA-E6-A1LX	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.0556
p.R190C	DO41020	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.0556
p.R190C	DO41758	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.0556
p.L189I	TCGA-BF-A1PU	SKCM	TCGA	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.0833
p.L189I	DO50278	SKCM	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.0833
p.D172Y	TCGA-DD-A73F	LIHC	TCGA	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.2222
p.G168S	TCGA-EE-A182	SKCM	TCGA	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1111
p.I183M	DO9876	COAD	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.25
p.R190L	DO229028	LICA	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.0556
p.V170L	DO229037	LICA	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1667
p.E174D	DO25153	LUAD	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.2778
p.E174D	DO50075	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.2778
p.I183S	DO46657	PAAD	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.25
p.S187F	DO229502	SKCA	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1389
p.S187F	DO37639	SKCM	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1389
p.S187F	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1389
p.G166S	DO223907	SKCM	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.0556
p.R168M	DO41999	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1111
p.F175C	DO43907	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.3056
p.V187I	SIDM00120	Prostate Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1389
p.V187I	ACH-000979	Prostate Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1389
p.V187I	DU-145	prostate	COSMIC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1389
p.G168E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1111
p.D170N	GR-ST	haematopoietic and lymphoid tissue	COSMIC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1667
p.H188Y	COLO-792	skin	COSMIC	DKENT	DEG_APCC_KENBOX_2	176:180	Mutation rewiring degron network	0.1111

Kaplan plot for RAPGEF4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAPGEF4

UniProt ID: Q8WZA2

Entrez ID: 11069

Protein name: Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAPGEF4 in