DegronMD

Uniprot ID: Q8WZA2

Source protein: Rap guanine nucleotide exchange factor 4

Source gene: RAPGEF4

Class: DEG_APCC_KENBOX_2

Location: 176:180

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5031

ASA_SCORE: 111.44

COIL: 0.9262

CONS_SCORE: 0.2485

DSS_SCORE: 0.6229

HELIX: 0.0424

FCONS_SCORE: 0.9364

RIG_SCORE: 0.6867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R190C	TCGA-B5-A1MR	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	0.0556
p.R190C	TCGA-E6-A1LX	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	0.0556
p.R190C	DO41020	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.0556
p.R190C	DO41758	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.0556
p.L189I	TCGA-BF-A1PU	SKCM	TCGA	DKENT	DEG_APCC_KENBOX_2	0.0833
p.L189I	DO50278	SKCM	ICGC	DKENT	DEG_APCC_KENBOX_2	0.0833
p.D172Y	TCGA-DD-A73F	LIHC	TCGA	DKENT	DEG_APCC_KENBOX_2	0.2222
p.G168S	TCGA-EE-A182	SKCM	TCGA	DKENT	DEG_APCC_KENBOX_2	0.1111
p.I183M	DO9876	COAD	ICGC	DKENT	DEG_APCC_KENBOX_2	0.25
p.R190L	DO229028	LICA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.0556
p.V170L	DO229037	LICA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1667
p.E174D	DO25153	LUAD	ICGC	DKENT	DEG_APCC_KENBOX_2	0.2778
p.E174D	DO50075	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.2778
p.I183S	DO46657	PAAD	ICGC	DKENT	DEG_APCC_KENBOX_2	0.25
p.S187F	DO229502	SKCA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1389
p.S187F	DO37639	SKCM	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1389
p.S187F	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.1389
p.G166S	DO223907	SKCM	ICGC	DKENT	DEG_APCC_KENBOX_2	0.0556
p.R168M	DO41999	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1111
p.F175C	DO43907	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.3056
p.V187I	SIDM00120	Prostate Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.1389
p.V187I	ACH-000979	Prostate Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	0.1389
p.V187I	DU-145	prostate	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.1389
p.G168E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.1111
p.D170N	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.1667
p.H188Y	COLO-792	skin	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31350	Ribonucleoside-diphosphate reductase subunit M2	DEG_APCC_KENBOX_2	29:33	DKENT	APC,CDC20,FZR1	0.9969	More...
Q8WZA2	Rap guanine nucleotide exchange factor 4	DEG_APCC_KENBOX_2	176:180	DKENT	APC,CDC20,FZR1	0.5031	More...
Q96MA1	Doublesex- and mab-3-related transcription factor B1	DEG_APCC_KENBOX_2	316:320	DKENT	APC,CDC20,FZR1	0.7162	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	923:927	DKENT	APC,CDC20,FZR1	0.7191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DKENT

Degron related mutations and impact score

Drug responses associated with RAPGEF4 mutations

All proteins holding degron of DKENT