DegronMD - Q96MA1(DMRTB1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q323K	TCGA-05-4382	LUAD	TCGA	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.25
p.Q323K	DO24900	LUAD	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.25
p.T320N	TCGA-64-5775	LUAD	TCGA	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.5944
p.T320N	DO26025	LUAD	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.5944
p.V311A	TCGA-69-A59K	LUAD	TCGA	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1944
p.V311A	DO45335	LUAD	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1944
p.P276T	TCGA-78-8662	LUAD	TCGA	PPGY	ITCH	285:288	Mutation rewiring degron network	0.0833
p.P276T	DO45346	LUAD	ICGC	PPGY	ITCH	285:288	Mutation rewiring degron network	0.0833
p.V311I	TCGA-AP-A059	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1944
p.V311I	DO230309	COCA	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1944
p.V311I	DO41361	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1944
p.E318D	TCGA-AX-A05Z	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.6758
p.E318D	DO40884	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.6758
p.L292H	TCGA-EO-A22R	UCEC	TCGA	PPGY	ITCH	285:288	Mutation rewiring degron network	0.2222
p.L292H	DO42713	UCEC	ICGC	PPGY	ITCH	285:288	Mutation rewiring degron network	0.2222
p.L309M	TCGA-EO-A3AU	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1389
p.L309M	DO43827	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1389
p.F307L	TCGA-F5-6814	READ	TCGA	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.0833
p.F307L	DO36556	READ	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.0833
p.A291V	TCGA-HU-A4H4	STAD	TCGA	PPGY	ITCH	285:288	Mutation rewiring degron network	0.25
p.A291V	DO47721	STAD	ICGC	PPGY	ITCH	285:288	Mutation rewiring degron network	0.25
p.P276Q	TCGA-IG-A3YA	ESCA	TCGA	PPGY	ITCH	285:288	Mutation rewiring degron network	0.0833
p.D316Y	TCGA-KQ-A41N	BLCA	TCGA	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.6214
p.D316Y	DO223588	BLCA	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.6214
p.L295P	DO228404	BRCA	ICGC	PPGY	ITCH	285:288	Mutation rewiring degron network	0.1389
p.V327L	DO233947	GACA	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1389
p.V327L	DO229032	LICA	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1389
p.S308L	DO220906	MELA	ICGC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1111
p.T315N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.3056
p.T315N	ACH-002256	Leukemia	CCLE	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.3056
p.T315N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.3056
p.P285T	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	285:288	Mutation altering degron motif	0.7031
p.P285T	ACH-000960	Leukemia	CCLE	PPGY	ITCH	285:288	Mutation altering degron motif	0.7031
p.P285T	REH	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	285:288	Mutation altering degron motif	0.7031
p.E318K	SIDM00296	Small Cell Lung Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.7022
p.E318K	ACH-002051	Lung Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.7022
p.E318K	LU-134-A	lung	COSMIC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.7022
p.F307V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.0833
p.F307V	ACH-000823	Esophageal Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.0833
p.F307V	KYSE-140	oesophagus	COSMIC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.0833
p.G287A	SIDM00092	Ovarian Carcinoma	GDSC	PPGY	ITCH	285:288	Mutation altering degron motif	0.6429
p.G287A	ACH-000617	Ovarian Cancer	CCLE	PPGY	ITCH	285:288	Mutation altering degron motif	0.6429
p.G287A	OVCAR-4	ovary	COSMIC	PPGY	ITCH	285:288	Mutation altering degron motif	0.6429
p.N319D	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.6932
p.N319D	ACH-000929	Lung Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.6932
p.N319D	NCI-H2110	lung	COSMIC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation altering degron motif	0.6932
p.H293Q	SIDM01228	Melanoma	GDSC	PPGY	ITCH	285:288	Mutation rewiring degron network	0.1944
p.H293Q	ACH-001024	Skin Cancer	CCLE	PPGY	ITCH	285:288	Mutation rewiring degron network	0.1944
p.H293Q	CHL-1	skin	COSMIC	PPGY	ITCH	285:288	Mutation rewiring degron network	0.1944
p.T310I	SIDM00901	Endometrial Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1667
p.T310I	ACH-000940	Endometrial/Uterine Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1667
p.T310I	AN3-CA	endometrium	COSMIC	DKENT	DEG_APCC_KENBOX_2	316:320	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMRTB1

UniProt ID: Q96MA1

Entrez ID: 63948

Protein name: Doublesex- and mab-3-related transcription factor B1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMRTB1 in