DegronMD

Uniprot ID: Q96MA1

Source protein: Doublesex- and mab-3-related transcription factor B1

Source gene: DMRTB1

Class: DEG_APCC_KENBOX_2

Location: 316:320

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7162

ASA_SCORE: 102.64

COIL: 0.8242

CONS_SCORE: 0.9005

DSS_SCORE: 0.7078

HELIX: 0.1242

FCONS_SCORE: 1.2434

RIG_SCORE: 0.6657

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q323K	TCGA-05-4382	LUAD	TCGA	DKENT	DEG_APCC_KENBOX_2	0.25
p.Q323K	DO24900	LUAD	ICGC	DKENT	DEG_APCC_KENBOX_2	0.25
p.T320N	TCGA-64-5775	LUAD	TCGA	DKENT	DEG_APCC_KENBOX_2	0.5944
p.T320N	DO26025	LUAD	ICGC	DKENT	DEG_APCC_KENBOX_2	0.5944
p.V311A	TCGA-69-A59K	LUAD	TCGA	DKENT	DEG_APCC_KENBOX_2	0.1944
p.V311A	DO45335	LUAD	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1944
p.V311I	TCGA-AP-A059	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	0.1944
p.V311I	DO230309	COCA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1944
p.V311I	DO41361	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1944
p.E318D	TCGA-AX-A05Z	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	0.6758
p.E318D	DO40884	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.6758
p.L309M	TCGA-EO-A3AU	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	0.1389
p.L309M	DO43827	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1389
p.F307L	TCGA-F5-6814	READ	TCGA	DKENT	DEG_APCC_KENBOX_2	0.0833
p.F307L	DO36556	READ	ICGC	DKENT	DEG_APCC_KENBOX_2	0.0833
p.D316Y	TCGA-KQ-A41N	BLCA	TCGA	DKENT	DEG_APCC_KENBOX_2	0.6214
p.D316Y	DO223588	BLCA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.6214
p.V327L	DO233947	GACA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1389
p.V327L	DO229032	LICA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1389
p.S308L	DO220906	MELA	ICGC	DKENT	DEG_APCC_KENBOX_2	0.1111
p.T315N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DKENT	DEG_APCC_KENBOX_2	0.3056
p.T315N	ACH-002256	Leukemia	CCLE	DKENT	DEG_APCC_KENBOX_2	0.3056
p.T315N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.3056
p.E318K	SIDM00296	Small Cell Lung Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.7022
p.E318K	ACH-002051	Lung Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	0.7022
p.E318K	LU-134-A	lung	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.7022
p.F307V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.0833
p.F307V	ACH-000823	Esophageal Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	0.0833
p.F307V	KYSE-140	oesophagus	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.0833
p.N319D	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.6932
p.N319D	ACH-000929	Lung Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	0.6932
p.N319D	NCI-H2110	lung	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.6932
p.T310I	SIDM00901	Endometrial Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	0.1667
p.T310I	ACH-000940	Endometrial/Uterine Cancer	CCLE	DKENT	DEG_APCC_KENBOX_2	0.1667
p.T310I	AN3-CA	endometrium	COSMIC	DKENT	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31350	Ribonucleoside-diphosphate reductase subunit M2	DEG_APCC_KENBOX_2	29:33	DKENT	APC,CDC20,FZR1	0.9969	More...
Q8WZA2	Rap guanine nucleotide exchange factor 4	DEG_APCC_KENBOX_2	176:180	DKENT	APC,CDC20,FZR1	0.5031	More...
Q96MA1	Doublesex- and mab-3-related transcription factor B1	DEG_APCC_KENBOX_2	316:320	DKENT	APC,CDC20,FZR1	0.7162	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	923:927	DKENT	APC,CDC20,FZR1	0.7191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DKENT

Degron related mutations and impact score

Drug responses associated with DMRTB1 mutations

All proteins holding degron of DKENT