DegronMD - P31350(RRM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A23T	TCGA-D1-A17A	UCEC	TCGA	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation blocking ubiquitination signal	0.6111
p.A23T	TCGA-D1-A17A	UCEC	TCGA	LAPITDPQQLQL	DEG_ODPH_VHL_1	8:19	Mutation blocking ubiquitination signal	0.6667
p.A23T	DO43875	UCEC	ICGC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation blocking ubiquitination signal	0.6111
p.A23T	DO43875	UCEC	ICGC	LAPITDPQQLQL	DEG_ODPH_VHL_1	8:19	Mutation blocking ubiquitination signal	0.6667
p.A26S	DO229026	LICA	ICGC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation blocking phosphorylation signal	0.6944
p.A26S	DO229026	LICA	ICGC	LAPITDPQQLQL	DEG_ODPH_VHL_1	8:19	Mutation blocking phosphorylation signal	0.5833
p.Q15R	DO23496	LINC	ICGC	LAPITDPQQLQL	DEG_ODPH_VHL_1	8:19	Mutation altering degron motif	0.6218
p.Q15R	DO45053	LINC	ICGC	LAPITDPQQLQL	DEG_ODPH_VHL_1	8:19	Mutation altering degron motif	0.6218
p.G39W	DO229257	THCA	ICGC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.1667
p.V37I	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.2222
p.V37I	SIDM00232	Kidney Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.2222
p.S29L	SIDM00656	Burkitt's Lymphoma	GDSC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation altering degron motif	0.7667
p.S29L	SIDM00641	Burkitt's Lymphoma	GDSC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation altering degron motif	0.7667
p.M26L	SIDM00507	Other Solid Cancers	GDSC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation blocking phosphorylation signal	0.6944
p.M26L	SIDM00507	Other Solid Cancers	GDSC	LAPITDPQQLQL	DEG_ODPH_VHL_1	8:19	Mutation blocking phosphorylation signal	0.5833
p.P35H	SIDM00251	Gastric Carcinoma	GDSC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.2778
p.C34R	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.3056
p.V42A	ACH-000889	Myeloma	CCLE	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.0833
p.L27F	NOS-1	bone	COSMIC	DKENT	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.2778
p.L27F	NOS-1	bone	COSMIC	LAPITDPQQLQL	DEG_ODPH_VHL_1	8:19	Mutation rewiring degron network	0.1111

Kaplan plot for RRM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RRM2

UniProt ID: P31350

Entrez ID: 6241

Protein name: Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RRM2 in