DegronMD

Uniprot ID: P31350

Source protein: Ribonucleoside-diphosphate reductase subunit M2

Source gene: RRM2

Class: DEG_ODPH_VHL_1

Location: 8:19

E3 ligase: VHL

DEGRON score: 0.9387

ASA_SCORE: 84.7917

COIL: 0.718

CONS_SCORE: 0.2019

DSS_SCORE: 0.339

HELIX: 0.2435

FCONS_SCORE: 0.8321

RIG_SCORE: 0.7553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A23T	TCGA-D1-A17A	UCEC	TCGA	LAPITDPQQLQL	DEG_ODPH_VHL_1	0.6667
p.A23T	DO43875	UCEC	ICGC	LAPITDPQQLQL	DEG_ODPH_VHL_1	0.6667
p.A26S	DO229026	LICA	ICGC	LAPITDPQQLQL	DEG_ODPH_VHL_1	0.5833
p.Q15R	DO23496	LINC	ICGC	LAPITDPQQLQL	DEG_ODPH_VHL_1	0.6218
p.Q15R	DO45053	LINC	ICGC	LAPITDPQQLQL	DEG_ODPH_VHL_1	0.6218
p.M26L	SIDM00507	Other Solid Cancers	GDSC	LAPITDPQQLQL	DEG_ODPH_VHL_1	0.5833
p.L27F	NOS-1	bone	COSMIC	LAPITDPQQLQL	DEG_ODPH_VHL_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31350	Ribonucleoside-diphosphate reductase subunit M2	DEG_ODPH_VHL_1	8:19	LAPITDPQQLQL	VHL	0.9387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons