DegronMD

Uniprot ID: Q92628

Source protein: Uncharacterized protein KIAA0232

Source gene: KIAA0232

Class: DEG_APCC_KENBOX_2

Location: 254:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 112.6

COIL: 0.5476

CONS_SCORE: 0.7435

DSS_SCORE: 0.6262

HELIX: 0.427

FCONS_SCORE: 1.4757

RIG_SCORE: 0.6593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E266A	TCGA-BS-A0UF	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1111
p.E266A	DO41488	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1111
p.H244Y	TCGA-CM-4746	COAD	TCGA	EKENK	DEG_APCC_KENBOX_2	0.0556
p.H244Y	DO7882	COAD	ICGC	EKENK	DEG_APCC_KENBOX_2	0.0556
p.E254K	TCGA-FW-A3R5	SKCM	TCGA	EKENK	DEG_APCC_KENBOX_2	0.591
p.E254K	DO37406	SKCM	ICGC	EKENK	DEG_APCC_KENBOX_2	0.591
p.G262C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	0.2222
p.G262C	ACH-001669	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	0.2222
p.G262C	ACH-002238	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	0.2222
p.G262C	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07550	Beta-2 adrenergic receptor	DEG_APCC_KENBOX_2	371:375	EKENK	APC,CDC20,FZR1	0.9351	More...
P17844	Probable ATP-dependent RNA helicase DDX5	DEG_APCC_KENBOX_2	339:343	EKENK	APC,CDC20,FZR1	0.5974	More...
P48681	Nestin	DEG_APCC_KENBOX_2	590:594	EKENK	APC,CDC20,FZR1	0.979	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	586:590	EKENK	APC,CDC20,FZR1	0.693	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_APCC_KENBOX_2	1632:1636	EKENK	APC,CDC20,FZR1	0.9775	More...
Q96HR8	H/ACA ribonucleoprotein complex non-core subunit NAF1	DEG_APCC_KENBOX_2	163:167	EKENK	APC,CDC20,FZR1	0.962	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	589:593	EKENK	APC,CDC20,FZR1	0.9822	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_KENBOX_2	234:238	EKENK	APC,CDC20,FZR1	0.9886	More...
Q5T9S5	Coiled-coil domain-containing protein 18	DEG_APCC_KENBOX_2	281:285	EKENK	APC,CDC20,FZR1	0.6092	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	254:258	EKENK	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons