DegronMD

Uniprot ID: P17844

Source protein: Probable ATP-dependent RNA helicase DDX5

Source gene: DDX5

Class: DEG_APCC_KENBOX_2

Location: 339:343

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5974

ASA_SCORE: 88.94

COIL: 0.796

CONS_SCORE: 0.4003

DSS_SCORE: 0.2498

HELIX: 0.1462

FCONS_SCORE: 0.6936

RIG_SCORE: 0.7802

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R331C	TCGA-BH-A0DZ	BRCA	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1111
p.R331C	DO2919	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1111
p.R331C	DO222755	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1111
p.T350S	DO222880	MELA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1389
p.R352G	DO231284	PACA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.0833
p.K343T	SIDM00534	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.6195
p.K343T	ACH-000986	Colon/Colorectal Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.6195
p.K343T	HT-115	large_intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.6195

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07550	Beta-2 adrenergic receptor	DEG_APCC_KENBOX_2	371:375	EKENK	APC,CDC20,FZR1	0.9351	More...
P17844	Probable ATP-dependent RNA helicase DDX5	DEG_APCC_KENBOX_2	339:343	EKENK	APC,CDC20,FZR1	0.5974	More...
P48681	Nestin	DEG_APCC_KENBOX_2	590:594	EKENK	APC,CDC20,FZR1	0.979	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	586:590	EKENK	APC,CDC20,FZR1	0.693	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_APCC_KENBOX_2	1632:1636	EKENK	APC,CDC20,FZR1	0.9775	More...
Q96HR8	H/ACA ribonucleoprotein complex non-core subunit NAF1	DEG_APCC_KENBOX_2	163:167	EKENK	APC,CDC20,FZR1	0.962	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	589:593	EKENK	APC,CDC20,FZR1	0.9822	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_KENBOX_2	234:238	EKENK	APC,CDC20,FZR1	0.9886	More...
Q5T9S5	Coiled-coil domain-containing protein 18	DEG_APCC_KENBOX_2	281:285	EKENK	APC,CDC20,FZR1	0.6092	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	254:258	EKENK	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons