DegronMD

Uniprot ID: Q53SF7

Source protein: Cordon-bleu protein-like 1

Source gene: COBLL1

Class: DEG_APCC_KENBOX_2

Location: 234:238

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9886

ASA_SCORE: 108.06

COIL: 0.551

CONS_SCORE: 0.5098

DSS_SCORE: 0.3236

HELIX: 0.412

FCONS_SCORE: 1.0763

RIG_SCORE: 0.7707

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N228H	TCGA-19-5956	GBM	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1667
p.N228H	DO13863	GBM	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.E234D	TCGA-BS-A0UF	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.5647
p.E234D	DO41488	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.5647
p.I231V	TCGA-DU-7294	LGG	TCGA	EKENK	DEG_APCC_KENBOX_2	0.25
p.I231V	DO22333	LGG	ICGC	EKENK	DEG_APCC_KENBOX_2	0.25
p.K235T	TCGA-EO-A22R	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.7306
p.K235T	DO42713	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.7306
p.R246C	TCGA-LT-A5Z6	BLCA	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1111
p.R246C	DO44029	BLCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1111
p.R246C	DO233784	GACA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1111
p.F240V	DO233955	BPLL	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2778
p.I225V	DO225120	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.0833
p.I225V	DO227903	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.0833
p.D245E	DO229035	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1389
p.H239R	SIDM00659	Glioblastoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.H239R	SIDM00695	Melanoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.H239R	M059J	central_nervous_system	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.H239R	HT-144	skin	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.D236V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	0.7785
p.D236V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.7785
p.I229V	SIDM00417	Plasma Cell Myeloma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1944
p.I229V	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1944
p.C233Y	SIDM00214	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.C233Y	SNU-407	large_intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.S231N	SIDM01609	Endometrial Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.25
p.H224R	HT-144	skin	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.0556
p.H224R	M059J	central_nervous_system	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07550	Beta-2 adrenergic receptor	DEG_APCC_KENBOX_2	371:375	EKENK	APC,CDC20,FZR1	0.9351	More...
P17844	Probable ATP-dependent RNA helicase DDX5	DEG_APCC_KENBOX_2	339:343	EKENK	APC,CDC20,FZR1	0.5974	More...
P48681	Nestin	DEG_APCC_KENBOX_2	590:594	EKENK	APC,CDC20,FZR1	0.979	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	586:590	EKENK	APC,CDC20,FZR1	0.693	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_APCC_KENBOX_2	1632:1636	EKENK	APC,CDC20,FZR1	0.9775	More...
Q96HR8	H/ACA ribonucleoprotein complex non-core subunit NAF1	DEG_APCC_KENBOX_2	163:167	EKENK	APC,CDC20,FZR1	0.962	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	589:593	EKENK	APC,CDC20,FZR1	0.9822	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_KENBOX_2	234:238	EKENK	APC,CDC20,FZR1	0.9886	More...
Q5T9S5	Coiled-coil domain-containing protein 18	DEG_APCC_KENBOX_2	281:285	EKENK	APC,CDC20,FZR1	0.6092	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	254:258	EKENK	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EKENK

Degron related mutations and impact score

Drug responses associated with COBLL1 mutations

All proteins holding degron of EKENK