DegronMD - Q96HR8(NAF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P475L	TCGA-37-4135	LUSC	TCGA	NLPYSLPP	CBL_PTK	463:470	Mutation rewiring degron network	0.1944
p.P475L	DO26806	LUSC	ICGC	NLPYSLPP	CBL_PTK	463:470	Mutation rewiring degron network	0.1944
p.K174E	TCGA-44-7672	LUAD	TCGA	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation substituting flanking lysine	0.25
p.K174E	DO23576	LUAD	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation substituting flanking lysine	0.25
p.P472S	TCGA-76-4934	GBM	TCGA	NLPYSLPP	CBL_PTK	463:470	Mutation rewiring degron network	0.2778
p.P472S	DO12286	GBM	ICGC	NLPYSLPP	CBL_PTK	463:470	Mutation rewiring degron network	0.2778
p.Y466C	TCGA-AZ-6598	COAD	TCGA	NLPYSLPP	CBL_PTK	463:470	Mutation altering degron motif	0.7087
p.Y466C	DO10276	COAD	ICGC	NLPYSLPP	CBL_PTK	463:470	Mutation altering degron motif	0.7087
p.D157A	TCGA-E6-A1LX	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.1667
p.D157A	DO41020	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.1667
p.K172N	TCGA-EY-A1GI	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation substituting flanking lysine	0.3056
p.K172N	DO41211	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation substituting flanking lysine	0.3056
p.D175G	TCGA-F5-6814	READ	TCGA	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.1111
p.D175G	DO36556	READ	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.1111
p.P474L	TCGA-ZJ-AAXN	CESC	TCGA	NLPYSLPP	CBL_PTK	463:470	Mutation rewiring degron network	0.2222
p.P474L	DO219757	CESC	ICGC	NLPYSLPP	CBL_PTK	463:470	Mutation rewiring degron network	0.2222
p.D158N	DO217844	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.1944
p.I162V	DO229010	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.3056
p.I162V	DO229013	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.3056
p.I162V	DO229016	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.3056
p.I162V	DO229003	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.3056
p.I162V	DO229005	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.3056
p.Q161K	DO229026	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	163:167	Mutation rewiring degron network	0.2778
p.H459Y	SIDM00257	Neuroblastoma	GDSC	NLPYSLPP	CBL_PTK	463:470	Mutation rewiring degron network	0.2222
p.H459Y	NB13	autonomic ganglia	COSMIC	NLPYSLPP	CBL_PTK	463:470	Mutation rewiring degron network	0.2222

Kaplan plot for NAF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NAF1

UniProt ID: Q96HR8

Entrez ID: 92345

Protein name: H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NAF1 in