DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
NLPYSLPP
Uniprot ID:
Q96HR8
Source protein:
H/ACA ribonucleoprotein complex non-core subunit NAF1
Source gene:
NAF1
Class:
CBL_PTK
Location:
463:470
E3 ligase:
CBL
DEGRON score:
0.9856
ASA_SCORE:
71.35
COIL:
0.9765
CONS_SCORE:
0.2711
DSS_SCORE:
0.5551
HELIX:
0.0104
FCONS_SCORE:
0.9816
RIG_SCORE:
0.5892
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P475L
TCGA-37-4135
LUSC
TCGA
NLPYSLPP
CBL_PTK
0.1944
p.P475L
DO26806
LUSC
ICGC
NLPYSLPP
CBL_PTK
0.1944
p.P472S
TCGA-76-4934
GBM
TCGA
NLPYSLPP
CBL_PTK
0.2778
p.P472S
DO12286
GBM
ICGC
NLPYSLPP
CBL_PTK
0.2778
p.Y466C
TCGA-AZ-6598
COAD
TCGA
NLPYSLPP
CBL_PTK
0.7087
p.Y466C
DO10276
COAD
ICGC
NLPYSLPP
CBL_PTK
0.7087
p.P474L
TCGA-ZJ-AAXN
CESC
TCGA
NLPYSLPP
CBL_PTK
0.2222
p.P474L
DO219757
CESC
ICGC
NLPYSLPP
CBL_PTK
0.2222
p.H459Y
SIDM00257
Neuroblastoma
GDSC
NLPYSLPP
CBL_PTK
0.2222
p.H459Y
NB13
autonomic_ganglia
COSMIC
NLPYSLPP
CBL_PTK
0.2222
Drug responses associated with NAF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NLPYSLPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96HR8
H/ACA ribonucleoprotein complex non-core subunit NAF1
CBL_PTK
463:470
NLPYSLPP
CBL
0.9856
More...
