DegronMD

Uniprot ID: Q96HR8

Source protein: H/ACA ribonucleoprotein complex non-core subunit NAF1

Source gene: NAF1

Class: DEG_APCC_KENBOX_2

Location: 163:167

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.962

ASA_SCORE: 117.22

COIL: 0.6752

CONS_SCORE: 0.377

DSS_SCORE: 0.507

HELIX: 0.3184

FCONS_SCORE: 1.1502

RIG_SCORE: 0.7545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K174E	TCGA-44-7672	LUAD	TCGA	EKENK	DEG_APCC_KENBOX_2	0.25
p.K174E	DO23576	LUAD	ICGC	EKENK	DEG_APCC_KENBOX_2	0.25
p.D157A	TCGA-E6-A1LX	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1667
p.D157A	DO41020	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.K172N	TCGA-EY-A1GI	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.3056
p.K172N	DO41211	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.D175G	TCGA-F5-6814	READ	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1111
p.D175G	DO36556	READ	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1111
p.D158N	DO217844	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1944
p.I162V	DO229010	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.I162V	DO229013	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.I162V	DO229016	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.I162V	DO229003	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.I162V	DO229005	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.Q161K	DO229026	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07550	Beta-2 adrenergic receptor	DEG_APCC_KENBOX_2	371:375	EKENK	APC,CDC20,FZR1	0.9351	More...
P17844	Probable ATP-dependent RNA helicase DDX5	DEG_APCC_KENBOX_2	339:343	EKENK	APC,CDC20,FZR1	0.5974	More...
P48681	Nestin	DEG_APCC_KENBOX_2	590:594	EKENK	APC,CDC20,FZR1	0.979	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	586:590	EKENK	APC,CDC20,FZR1	0.693	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_APCC_KENBOX_2	1632:1636	EKENK	APC,CDC20,FZR1	0.9775	More...
Q96HR8	H/ACA ribonucleoprotein complex non-core subunit NAF1	DEG_APCC_KENBOX_2	163:167	EKENK	APC,CDC20,FZR1	0.962	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	589:593	EKENK	APC,CDC20,FZR1	0.9822	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_KENBOX_2	234:238	EKENK	APC,CDC20,FZR1	0.9886	More...
Q5T9S5	Coiled-coil domain-containing protein 18	DEG_APCC_KENBOX_2	281:285	EKENK	APC,CDC20,FZR1	0.6092	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	254:258	EKENK	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons