DegronMD - P17844(DDX5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D355H	TCGA-B8-A54E	KIRC	TCGA	KTIVFVE	LIG_APCC_ABBAyCdc20_2	343:349	Mutation rewiring degron network	0.1667
p.D355H	DO50478	KIRC	ICGC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	343:349	Mutation rewiring degron network	0.1667
p.R331C	TCGA-BH-A0DZ	BRCA	TCGA	EKENK	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1111
p.R331C	DO2919	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1111
p.R331C	DO222755	COCA	ICGC	EKENK	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1111
p.T350S	DO222880	MELA	ICGC	EKENK	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.1389
p.T350S	DO222880	MELA	ICGC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	343:349	Mutation rewiring degron network	0.3056
p.R352G	DO231284	PACA	ICGC	EKENK	DEG_APCC_KENBOX_2	339:343	Mutation rewiring degron network	0.0833
p.R352G	DO231284	PACA	ICGC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	343:349	Mutation rewiring degron network	0.25
p.K343T	SIDM00534	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6195
p.K343T	SIDM00534	Colorectal Carcinoma	GDSC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	343:349	Mutation altering degron motif	0.7306
p.K343T	ACH-000986	Colon/Colorectal Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6195
p.K343T	ACH-000986	Colon/Colorectal Cancer	CCLE	KTIVFVE	LIG_APCC_ABBAyCdc20_2	343:349	Mutation altering degron motif	0.7306
p.K343T	HT-115	large intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	339:343	Mutation altering degron motif	0.6195
p.K343T	HT-115	large intestine	COSMIC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	343:349	Mutation altering degron motif	0.7306
p.I347V	HCC1569	breast	COSMIC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	343:349	Mutation altering degron motif	0.7076

Kaplan plot for DDX5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDX5

UniProt ID: P17844

Entrez ID: 1655

Protein name: Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DDX5 in