DegronMD

Uniprot ID: P17844

Source protein: Probable ATP-dependent RNA helicase DDX5

Source gene: DDX5

Class: LIG_APCC_ABBAyCdc20_2

Location: 343:349

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8526

ASA_SCORE: 20.3429

COIL: 0.266

CONS_SCORE: 0.7102

DSS_SCORE: 0.3338

HELIX: 0.0153

FCONS_SCORE: 1.4028

RIG_SCORE: 0.8848

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D355H	TCGA-B8-A54E	KIRC	TCGA	KTIVFVE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D355H	DO50478	KIRC	ICGC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T350S	DO222880	MELA	ICGC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R352G	DO231284	PACA	ICGC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	0.25
p.K343T	SIDM00534	Colorectal Carcinoma	GDSC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	0.7306
p.K343T	ACH-000986	Colon/Colorectal Cancer	CCLE	KTIVFVE	LIG_APCC_ABBAyCdc20_2	0.7306
p.K343T	HT-115	large_intestine	COSMIC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	0.7306
p.I347V	HCC1569	breast	COSMIC	KTIVFVE	LIG_APCC_ABBAyCdc20_2	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17844	Probable ATP-dependent RNA helicase DDX5	LIG_APCC_ABBAyCdc20_2	343:349	KTIVFVE	APC,CDC20,FZR1	0.8526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons