DegronMD

Uniprot ID: Q5T9S5

Source protein: Coiled-coil domain-containing protein 18

Source gene: CCDC18

Class: DEG_APCC_KENBOX_2

Location: 281:285

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6092

ASA_SCORE: 117.1

COIL: 0.0254

CONS_SCORE: 0.647

DSS_SCORE: 0.2466

HELIX: 0.9758

FCONS_SCORE: 1.1939

RIG_SCORE: 0.7815

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R290Q	TCGA-AP-A1DV	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1944
p.Q281R	TCGA-DI-A1BU	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.7329
p.E280K	TCGA-S5-A6DX	BLCA	TCGA	EKENK	DEG_APCC_KENBOX_2	0.3056
p.E277Q	DO1088	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2222
p.C291W	DO4935	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.N295T	DO233740	GACA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.N284S	DO219704	KIRP	ICGC	EKENK	DEG_APCC_KENBOX_2	0.7069
p.R286S	DO229027	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.G292V	DO229027	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1389
p.E283K	DO229052	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.7022
p.E283K	SIDM00837	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.7022
p.E283K	ACH-000958	Colon/Colorectal Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.7022
p.E283K	SW48	large_intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.7022
p.Y294H	SIDM00217	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.0833
p.Y294H	ACH-000999	Colon/Colorectal Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.0833
p.Y294H	SNU-1040	large_intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07550	Beta-2 adrenergic receptor	DEG_APCC_KENBOX_2	371:375	EKENK	APC,CDC20,FZR1	0.9351	More...
P17844	Probable ATP-dependent RNA helicase DDX5	DEG_APCC_KENBOX_2	339:343	EKENK	APC,CDC20,FZR1	0.5974	More...
P48681	Nestin	DEG_APCC_KENBOX_2	590:594	EKENK	APC,CDC20,FZR1	0.979	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	586:590	EKENK	APC,CDC20,FZR1	0.693	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_APCC_KENBOX_2	1632:1636	EKENK	APC,CDC20,FZR1	0.9775	More...
Q96HR8	H/ACA ribonucleoprotein complex non-core subunit NAF1	DEG_APCC_KENBOX_2	163:167	EKENK	APC,CDC20,FZR1	0.962	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	589:593	EKENK	APC,CDC20,FZR1	0.9822	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_KENBOX_2	234:238	EKENK	APC,CDC20,FZR1	0.9886	More...
Q5T9S5	Coiled-coil domain-containing protein 18	DEG_APCC_KENBOX_2	281:285	EKENK	APC,CDC20,FZR1	0.6092	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	254:258	EKENK	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons