DegronMD - Q5T9S5(CCDC18)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R290Q	TCGA-AP-A1DV	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1944
p.Y108C	TCGA-B0-5693	KIRC	TCGA	LREKLNKLR	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1111
p.Q281R	TCGA-DI-A1BU	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation altering degron motif	0.7329
p.E280K	TCGA-S5-A6DX	BLCA	TCGA	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.3056
p.E116Q	TCGA-ZF-AA53	BLCA	TCGA	LREKLNKLR	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.6744
p.E277Q	DO1088	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.2222
p.C291W	DO4935	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1667
p.A107T	DO222953	BTCA	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.0833
p.R1352H	DO230343	COCA	ICGC	FKIHGD	LIG_APCC_ABBA_1	1361:1366	Mutation rewiring degron network	0.0833
p.N295T	DO233740	GACA	ICGC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation substituting flanking lysine	0.1667
p.V131I	DO15807	HNSC	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1389
p.N284S	DO219704	KIRP	ICGC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation altering degron motif	0.7069
p.R286S	DO229027	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.3056
p.G292V	DO229027	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1389
p.E283K	DO229052	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation altering degron motif	0.7022
p.E283K	SIDM00837	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation altering degron motif	0.7022
p.E283K	ACH-000958	Colon/Colorectal Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation altering degron motif	0.7022
p.E283K	SW48	large intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation altering degron motif	0.7022
p.A1356S	DO229009	LICA	ICGC	FKIHGD	LIG_APCC_ABBA_1	1361:1366	Mutation rewiring degron network	0.1944
p.L111F	DO230990	LUSC	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1944
p.L120R	DO50291	SKCM	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.8428
p.Q125R	DO229248	THCA	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.3056
p.E133D	DO42033	UCEC	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.0833
p.Q133H	DO43186	UCEC	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.0833
p.G1365S	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	FKIHGD	LIG_APCC_ABBA_1	1361:1366	Mutation altering degron motif	0.5882
p.G1365S	ACH-000980	Lung Cancer	CCLE	FKIHGD	LIG_APCC_ABBA_1	1361:1366	Mutation altering degron motif	0.5882
p.G1365S	NCI-H1155	lung	COSMIC	FKIHGD	LIG_APCC_ABBA_1	1361:1366	Mutation altering degron motif	0.5882
p.Y294H	SIDM00217	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.0833
p.Y294H	ACH-000999	Colon/Colorectal Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.0833
p.Y294H	SNU-1040	large intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC18

UniProt ID: Q5T9S5

Entrez ID: 343099

Protein name: Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CCDC18 in