DegronMD

Uniprot ID: Q5T9S5

Source protein: Coiled-coil domain-containing protein 18

Source gene: CCDC18

Class: LIG_APCC_ABBA_1

Location: 1361:1366

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8723

ASA_SCORE: 99.3

COIL: 0.7548

CONS_SCORE: 0.2598

DSS_SCORE: 0.2901

HELIX: 0.172

FCONS_SCORE: 0.7939

RIG_SCORE: 0.7616

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1352H	DO230343	COCA	ICGC	FKIHGD	LIG_APCC_ABBA_1	0.0833
p.A1356S	DO229009	LICA	ICGC	FKIHGD	LIG_APCC_ABBA_1	0.1944
p.G1365S	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	FKIHGD	LIG_APCC_ABBA_1	0.5882
p.G1365S	ACH-000980	Lung Cancer	CCLE	FKIHGD	LIG_APCC_ABBA_1	0.5882
p.G1365S	NCI-H1155	lung	COSMIC	FKIHGD	LIG_APCC_ABBA_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T9S5	Coiled-coil domain-containing protein 18	LIG_APCC_ABBA_1	1361:1366	FKIHGD	APC,CDC20,FZR1	0.8723	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons