DegronMD

Uniprot ID: Q5T9S5

Source protein: Coiled-coil domain-containing protein 18

Source gene: CCDC18

Class: DEG_APCC_DBOX_1

Location: 116:124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8686

ASA_SCORE: 110.2444

COIL: 0.013

CONS_SCORE: 0.6274

DSS_SCORE: 0.3856

HELIX: 0.9879

FCONS_SCORE: 1.201

RIG_SCORE: 0.7871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y108C	TCGA-B0-5693	KIRC	TCGA	LREKLNKLR	DEG_APCC_DBOX_1	0.1111
p.E116Q	TCGA-ZF-AA53	BLCA	TCGA	LREKLNKLR	DEG_APCC_DBOX_1	0.6744
p.A107T	DO222953	BTCA	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	0.0833
p.V131I	DO15807	HNSC	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	0.1389
p.L111F	DO230990	LUSC	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	0.1944
p.L120R	DO50291	SKCM	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	0.8428
p.Q125R	DO229248	THCA	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	0.3056
p.E133D	DO42033	UCEC	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	0.0833
p.Q133H	DO43186	UCEC	ICGC	LREKLNKLR	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T9S5	Coiled-coil domain-containing protein 18	DEG_APCC_DBOX_1	116:124	LREKLNKLR	APC,CDC20,FZR1	0.8686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons