DegronMD

Uniprot ID: P07550

Source protein: Beta-2 adrenergic receptor

Source gene: ADRB2

Class: DEG_APCC_KENBOX_2

Location: 371:375

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9351

ASA_SCORE: 114.56

COIL: 0.5776

CONS_SCORE: 0.5069

DSS_SCORE: 0.5411

HELIX: 0.3288

FCONS_SCORE: 1.0642

RIG_SCORE: 0.7724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V368L	TCGA-EE-A184	SKCM	TCGA	EKENK	DEG_APCC_KENBOX_2	0.25
p.V368L	DO47442	SKCM	ICGC	EKENK	DEG_APCC_KENBOX_2	0.25
p.K372N	TCGA-YC-A89H	BLCA	TCGA	EKENK	DEG_APCC_KENBOX_2	0.6918
p.K372N	DO51948	BLCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.6918
p.P382L	DO33091	PACA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1389
p.T384M	DO232761	PBCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.5278
p.S364R	DO229453	SKCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.5833
p.D380H	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1944
p.D380H	ACH-000916	Lung Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1944
p.D380H	NCI-H1573	lung	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07550	Beta-2 adrenergic receptor	DEG_APCC_KENBOX_2	371:375	EKENK	APC,CDC20,FZR1	0.9351	More...
P17844	Probable ATP-dependent RNA helicase DDX5	DEG_APCC_KENBOX_2	339:343	EKENK	APC,CDC20,FZR1	0.5974	More...
P48681	Nestin	DEG_APCC_KENBOX_2	590:594	EKENK	APC,CDC20,FZR1	0.979	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	586:590	EKENK	APC,CDC20,FZR1	0.693	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_APCC_KENBOX_2	1632:1636	EKENK	APC,CDC20,FZR1	0.9775	More...
Q96HR8	H/ACA ribonucleoprotein complex non-core subunit NAF1	DEG_APCC_KENBOX_2	163:167	EKENK	APC,CDC20,FZR1	0.962	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	589:593	EKENK	APC,CDC20,FZR1	0.9822	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_KENBOX_2	234:238	EKENK	APC,CDC20,FZR1	0.9886	More...
Q5T9S5	Coiled-coil domain-containing protein 18	DEG_APCC_KENBOX_2	281:285	EKENK	APC,CDC20,FZR1	0.6092	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	254:258	EKENK	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons