DegronMD

Uniprot ID: Q9P219

Source protein: Protein Daple

Source gene: CCDC88C

Class: DEG_APCC_KENBOX_2

Location: 589:593

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9822

ASA_SCORE: 121.08

COIL: 0.0174

CONS_SCORE: 0.3729

DSS_SCORE: 0.545

HELIX: 0.9836

FCONS_SCORE: 1.1985

RIG_SCORE: 0.6982

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E582K	TCGA-AJ-A3IA	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1389
p.E582K	DO43082	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1389
p.E601D	TCGA-AP-A051	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1111
p.E601D	DO42673	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1111
p.T600M	TCGA-AX-A2HC	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.1389
p.T600M	DO233016	GACA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1389
p.T600M	DO41572	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1389
p.M585I	TCGA-D9-A6EC	SKCM	TCGA	EKENK	DEG_APCC_KENBOX_2	0.2222
p.M585I	DO222708	MELA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2222
p.M585I	DO50291	SKCM	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2222
p.T598K	DO229019	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1944
p.T600K	DO229036	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1389
p.A583V	SIDM00435	Acute Myeloid Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	SIDM00437	Acute Myeloid Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	SIDM00617	Hepatocellular Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	SIDM00241	Breast Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	SIDM01617	Endometrial Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	SIDM01368	Gastric Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	SIDM01574	Plasma Cell Myeloma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	ACH-000074	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	ACH-000255	Gastric Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	ACH-000362	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	ACH-000369	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	ACH-000577	Liver Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	ACH-000588	Myeloma	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	ACH-000994	Endometrial/Uterine Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	ACH-001524	Skin Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	ACH-002179	Breast Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A583V	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.1667
p.A602P	SIDM01117	Small Cell Lung Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.0833
p.A602P	ACH-002176	Lung Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.0833
p.A602P	NCI-H748	lung	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.0833
p.S580N	SIDM00660	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.5278
p.S580N	ACH-000985	Colon/Colorectal Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.5278
p.S580N	LS-411N	large_intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.5278
p.V588M	SIDM00889	Cervical Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.V588M	ACH-001333	Cervical Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	0.3056
p.V588M	C-33-A	cervix	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.3056
p.K590R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	0.7237
p.K590R	SIDM00153	T-Lymphoblastic Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	0.7237
p.K590R	ACH-000964	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	0.7237
p.K590R	ACH-001127	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	0.7237
p.K590R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	0.7237
p.Q597R	SIDM01473	Plasma Cell Myeloma	GDSC	EKENK	DEG_APCC_KENBOX_2	0.2222
p.Q597R	ACH-000541	Myeloma	CCLE	EKENK	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07550	Beta-2 adrenergic receptor	DEG_APCC_KENBOX_2	371:375	EKENK	APC,CDC20,FZR1	0.9351	More...
P17844	Probable ATP-dependent RNA helicase DDX5	DEG_APCC_KENBOX_2	339:343	EKENK	APC,CDC20,FZR1	0.5974	More...
P48681	Nestin	DEG_APCC_KENBOX_2	590:594	EKENK	APC,CDC20,FZR1	0.979	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	586:590	EKENK	APC,CDC20,FZR1	0.693	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_APCC_KENBOX_2	1632:1636	EKENK	APC,CDC20,FZR1	0.9775	More...
Q96HR8	H/ACA ribonucleoprotein complex non-core subunit NAF1	DEG_APCC_KENBOX_2	163:167	EKENK	APC,CDC20,FZR1	0.962	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	589:593	EKENK	APC,CDC20,FZR1	0.9822	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_KENBOX_2	234:238	EKENK	APC,CDC20,FZR1	0.9886	More...
Q5T9S5	Coiled-coil domain-containing protein 18	DEG_APCC_KENBOX_2	281:285	EKENK	APC,CDC20,FZR1	0.6092	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	254:258	EKENK	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EKENK

Degron related mutations and impact score

Drug responses associated with CCDC88C mutations

All proteins holding degron of EKENK