DegronMD - Q6UB98(ANKRD12)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R582W	TCGA-06-5416	GBM	TCGA	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582W	TCGA-D1-A17Q	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582W	TCGA-DF-A2KU	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582W	TCGA-E6-A1LX	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582W	TCGA-IB-7651	PAAD	TCGA	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582W	DO10880	GBM	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582W	DO46657	PAAD	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582W	DO41020	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582W	DO223286	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582W	DO41903	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.P1880S	TCGA-19-5950	GBM	TCGA	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation rewiring degron network	0.1389
p.P1880S	DO11914	GBM	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation rewiring degron network	0.1389
p.P1898S	TCGA-78-8660	LUAD	TCGA	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation rewiring degron network	0.2222
p.P1898S	TCGA-EB-A3Y6	SKCM	TCGA	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation rewiring degron network	0.2222
p.P1898S	DO45321	LUAD	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation rewiring degron network	0.2222
p.P1898S	DO38081	SKCM	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation rewiring degron network	0.2222
p.R499K	TCGA-85-7696	LUSC	TCGA	GKENT	DEG_APCC_KENBOX_2	494:498	Mutation rewiring degron network	0.3056
p.R499K	DO26671	LUSC	ICGC	GKENT	DEG_APCC_KENBOX_2	494:498	Mutation rewiring degron network	0.3056
p.F590L	TCGA-A5-A2K5	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.F590L	TCGA-EY-A1GI	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.F590L	DO222884	COCA	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.F590L	DO41211	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.F590L	DO41379	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.V1641I	TCGA-BH-A0HF	BRCA	TCGA	EKENK	DEG_APCC_KENBOX_2	1632:1636	Mutation rewiring degron network	0.1944
p.V1641I	DO1749	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	1632:1636	Mutation rewiring degron network	0.1944
p.V1641F	TCGA-CC-A9FW	LIHC	TCGA	EKENK	DEG_APCC_KENBOX_2	1632:1636	Mutation rewiring degron network	0.1944
p.V1641F	DO219557	LIHC	ICGC	EKENK	DEG_APCC_KENBOX_2	1632:1636	Mutation rewiring degron network	0.1944
p.K492N	TCGA-DK-A2I1	BLCA	TCGA	GKENT	DEG_APCC_KENBOX_2	494:498	Mutation rewiring degron network	0.2778
p.K492N	DO444	BLCA	ICGC	GKENT	DEG_APCC_KENBOX_2	494:498	Mutation rewiring degron network	0.2778
p.L1645W	TCGA-ER-A193	SKCM	TCGA	EKENK	DEG_APCC_KENBOX_2	1632:1636	Mutation rewiring degron network	0.0833
p.L1645W	DO47368	SKCM	ICGC	EKENK	DEG_APCC_KENBOX_2	1632:1636	Mutation rewiring degron network	0.0833
p.V505L	TCGA-L9-A7SV	LUAD	TCGA	GKENT	DEG_APCC_KENBOX_2	494:498	Mutation rewiring degron network	0.1389
p.V505L	DO49875	LUAD	ICGC	GKENT	DEG_APCC_KENBOX_2	494:498	Mutation rewiring degron network	0.1389
p.E1634Q	TCGA-ZS-A9CE	LIHC	TCGA	EKENK	DEG_APCC_KENBOX_2	1632:1636	Mutation altering degron motif	0.6744
p.E1634Q	DO49720	LIHC	ICGC	EKENK	DEG_APCC_KENBOX_2	1632:1636	Mutation altering degron motif	0.6744
p.R1904L	DO231180	LAML	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation rewiring degron network	0.0556
p.R1904L	DO229034	LICA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation rewiring degron network	0.0556
p.K603N	DO228948	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation substituting flanking lysine	0.25
p.C600F	DO229029	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2222
p.D1877Y	DO229035	LICA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation rewiring degron network	0.0556
p.P1891L	DO220909	MELA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation altering degron motif	0.7582
p.P1887L	DO222710	MELA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation altering degron motif	0.6471
p.P1893T	DO233460	PRAD	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation altering degron motif	0.5919
p.S594I	DO229232	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.7341
p.P1891R	DO229240	THCA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation altering degron motif	0.7512
p.K598R	SIDM00216	Colorectal Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.K598R	ACH-000989	Colon/Colorectal Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.K598R	SNU-175	large intestine	COSMIC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.R582G	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582G	SIDM00056	Thyroid Gland Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582G	ACH-000766	Lung Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.R582G	ACH-002148	Thyroid Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.Q486E	SIDM01449	Pancreatic Carcinoma	GDSC	GKENT	DEG_APCC_KENBOX_2	494:498	Mutation rewiring degron network	0.1111
p.Q486E	ACH-000517	Pancreatic Cancer	CCLE	GKENT	DEG_APCC_KENBOX_2	494:498	Mutation rewiring degron network	0.1111
p.S594G	SIDM01450	Gastric Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.6993
p.S594G	ACH-000898	Gastric Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	592:596	Mutation altering degron motif	0.6993
p.L1890P	786-0	kidney	COSMIC	PTITPPPS	DEG_SCF_FBW7_1	1887:1894	Mutation altering degron motif	0.7582
p.D506G	NCI-H1993	lung	COSMIC	GKENT	DEG_APCC_KENBOX_2	494:498	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD12

UniProt ID: Q6UB98

Entrez ID: 23253

Protein name: Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD12 in