DegronMD

Uniprot ID: Q6UB98

Source protein: Ankyrin repeat domain-containing protein 12

Source gene: ANKRD12

Class: DEG_SCF_FBW7_1

Location: 1887:1894

E3 ligase: FBXW7

DEGRON score: 0.9343

ASA_SCORE: 78.725

COIL: 0.9525

CONS_SCORE: 0.4694

DSS_SCORE: 0.337

HELIX: 0.0223

FCONS_SCORE: 0.935

RIG_SCORE: 0.7307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1880S	TCGA-19-5950	GBM	TCGA	PTITPPPS	DEG_SCF_FBW7_1	0.1389
p.P1880S	DO11914	GBM	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.1389
p.P1898S	TCGA-78-8660	LUAD	TCGA	PTITPPPS	DEG_SCF_FBW7_1	0.2222
p.P1898S	TCGA-EB-A3Y6	SKCM	TCGA	PTITPPPS	DEG_SCF_FBW7_1	0.2222
p.P1898S	DO45321	LUAD	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.2222
p.P1898S	DO38081	SKCM	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.2222
p.R1904L	DO231180	LAML	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.0556
p.R1904L	DO229034	LICA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.0556
p.D1877Y	DO229035	LICA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.0556
p.P1891L	DO220909	MELA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.7582
p.P1887L	DO222710	MELA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.6471
p.P1893T	DO233460	PRAD	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.5919
p.P1891R	DO229240	THCA	ICGC	PTITPPPS	DEG_SCF_FBW7_1	0.7512
p.L1890P	786-0	kidney	COSMIC	PTITPPPS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_SCF_FBW7_1	1887:1894	PTITPPPS	FBXW7	0.9343	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons